Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death

Research output: Contribution to journalReview article

Abstract

Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4+ T cells and macrophages, which resist HIV-induced cell death. Understanding the potential mechanisms of how HIV-1 induces lymphocyte cell death is critical to the "kick and kill" cure strategy, which relies on the effective killing of reactivated, HIV-1-infected cells.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalAIDS Research and Human Retroviruses
Volume36
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • apoptosis
  • autophagy
  • human immunodeficiency virus
  • necroptosis

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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