Abstract
Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4+ T cells and macrophages, which resist HIV-induced cell death. Understanding the potential mechanisms of how HIV-1 induces lymphocyte cell death is critical to the "kick and kill" cure strategy, which relies on the effective killing of reactivated, HIV-1-infected cells.
Original language | English (US) |
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Pages (from-to) | 101-115 |
Number of pages | 15 |
Journal | AIDS Research and Human Retroviruses |
Volume | 36 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2020 |
Keywords
- apoptosis
- autophagy
- human immunodeficiency virus
- necroptosis
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases