Mechanisms of HIV-associated lymphocyte apoptosis

2010

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The inevitable decline of CD4T cells in untreated infection with the Human immunodeficiency virus (HIV) is due in large part to apoptosis, one type of programmed cell death. There is accumulating evidence that the accelerated apoptosis of CD4T cells in HIV infection is multifactorial, with direct viral cytotoxicity, signaling events triggered by viral proteins and aberrant immune activation adding to normal immune defense mechanisms to contribute to this phenomenon. Current antiviral treatment strategies generally lead to reduced apoptosis, but this approach may come at the cost of preserving latent viral reservoirs. It is the purpose of this review to provide an update on the current understanding of the role and mechanisms of accelerated apoptosis of T cells in the immunopathogenesis of HIV infection, and to highlight potential ways in which this seemingly deleterious process could be harnessed to not just control, but treat HIV infection.

Original languageEnglish (US)
Article numbere99
JournalCell Death and Disease
Volume1
Issue number11
DOIs
StatePublished - Nov 2010

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Virus Diseases
HIV
Lymphocytes
Apoptosis
Viral Proteins
Antiviral Agents
Cell Death
T-Lymphocytes
Infection

Keywords

  • Apoptosis
  • HIV
  • Immunopathogenesis
  • T-cel

ASJC Scopus subject areas

  • Cell Biology
  • Immunology
  • Cancer Research
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Mechanisms of HIV-associated lymphocyte apoptosis : 2010. / Cummins, Nathan W; Badley, Andrew David.

In: Cell Death and Disease, Vol. 1, No. 11, e99, 11.2010.

Research output: Contribution to journalArticle

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