Mechanisms of glioma invasion: Role of matrix-metalloproteinases

J. H. Uhm, N. P. Dooley, J. G. Villemure, V. W. Yong

Research output: Contribution to journalReview article

103 Citations (Scopus)

Abstract

One of the most lethal properties of high grade gliomas is their ability to invade the surrounding normal brain tissue, as infiltrated cells often escape surgical resection and inevitably lead to tumour recurrence. The consequent poor prognosis and survival rate underscore the need to further understand and target the cellular mechanisms that underly tumour invasiveness. Proteases which degrade the surrounding stromal cells and extracellular matrix proteins have been demonstrated to be critical effectors of invasion for tumours of both central and peripheral origin. Within the nervous system, the role of metalloproteinases as well as other classes of proteases in mediating the invasive phenotype of high grade gliomas has been an intense area of research. We present in this article a review of this literature and address the possibility that these proteases and the biochemical pathways that regulate their expression, such as protein kinase C, may represent potential targets in the therapy of high grade gliomas.

Original languageEnglish (US)
Pages (from-to)3-15
Number of pages13
JournalCanadian Journal of Neurological Sciences
Volume24
Issue number1
StatePublished - Feb 1997
Externally publishedYes

Fingerprint

Matrix Metalloproteinases
Glioma
Peptide Hydrolases
Neoplasms
Extracellular Matrix Proteins
Metalloproteases
Stromal Cells
Protein Kinase C
Nervous System
Phenotype
Recurrence
Brain
Research
Therapeutics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Uhm, J. H., Dooley, N. P., Villemure, J. G., & Yong, V. W. (1997). Mechanisms of glioma invasion: Role of matrix-metalloproteinases. Canadian Journal of Neurological Sciences, 24(1), 3-15.

Mechanisms of glioma invasion : Role of matrix-metalloproteinases. / Uhm, J. H.; Dooley, N. P.; Villemure, J. G.; Yong, V. W.

In: Canadian Journal of Neurological Sciences, Vol. 24, No. 1, 02.1997, p. 3-15.

Research output: Contribution to journalReview article

Uhm, JH, Dooley, NP, Villemure, JG & Yong, VW 1997, 'Mechanisms of glioma invasion: Role of matrix-metalloproteinases', Canadian Journal of Neurological Sciences, vol. 24, no. 1, pp. 3-15.
Uhm, J. H. ; Dooley, N. P. ; Villemure, J. G. ; Yong, V. W. / Mechanisms of glioma invasion : Role of matrix-metalloproteinases. In: Canadian Journal of Neurological Sciences. 1997 ; Vol. 24, No. 1. pp. 3-15.
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