Mechanisms in the pathogenesis of diabetic cardiomyopathy

Mohit Jain, Ronglih Liao, Thomas A. Miller, Nathan K. LeBrasseur, Douglas B. Sawyer

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Purpose of review: Diabetes results in the development of diabetic cardiomyopathy, a primary cardiac disease characterized pathologically by cardiomyocyte hypertrophy and apoptosis, and hemodynamically by impaired cardiac relaxation progressing to overt contractile failure. Despite the overwhelming incidence of diabetes, diabetic cardiomyopathy still remains a poorly understood disorder for which no established cause or specific treatment exists. Recent findings: Recent data in animal models of diabetes, as well as studies examining the role of metabolism in regulating myocardial phenotype, suggest that derangements in glucose metabolism and lipid transport may directly alter cardiac structure and function. In this review, we discuss the potential mechanisms underlying the development of diabetic cardiomyopathy. Summary: Recent findings will allow for greater insight into the pathogenesis of diabetic cardiomyopathy and allow for the development of novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalCurrent Opinion in Endocrinology and Diabetes
Volume10
Issue number4
DOIs
StatePublished - Aug 1 2003

Keywords

  • Apoptosis
  • Cardiomyocyte hypertrophy
  • Diabetic cardiomyopathy
  • Glucose metabolism
  • PPARα

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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