Mechanisms for the testicular hypertrophy which follows hemicastration

G. R. Cunningham, D. J. Tindall, C. Huckins, A. R. Means

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The hormonal and testicular effects of hemicastration have been examined using rodent models. When rats were hemicastrated at 5 days of age, significant testicular hypertrophy was noted within 5 days. Hypertrophy decreased as the age at hemicastration approached 20 days and did not occur in rats 45 days or older. The changes in testicular weight were associated with significant (P < 0.001) increases in serum FSH values from 10-20 days, but no significant alterations in the intratesticular concentration of testosterone occurred. Hemicastration also caused significant hypertrophy in testes depleted of germ cells. This was reflected by a substantial increase in testicular protein and DNA when compared to intact controls at 10, 15, and 20 days of age; however, the concentration of protein/μg DNA was increased only at 15 days. These data indicate that 1) changes in serum FSH and not intratesticular testosterone are associated with the testicular hypertrophy which follows unilateral castration of immature animals; 2) a significant proportion of the hypertrophy can be attributed to non-germinal cells, the Sertoli cell being the prime candidate; 3) the increase in testicular weight is primarily the result of an increase in cell number.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalEndocrinology
Volume102
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Hypertrophy
Testosterone
Weights and Measures
Sertoli Cells
Castration
DNA
Serum
Germ Cells
Testis
Rodentia
Proteins
Cell Count

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cunningham, G. R., Tindall, D. J., Huckins, C., & Means, A. R. (1978). Mechanisms for the testicular hypertrophy which follows hemicastration. Endocrinology, 102(1), 16-23.

Mechanisms for the testicular hypertrophy which follows hemicastration. / Cunningham, G. R.; Tindall, D. J.; Huckins, C.; Means, A. R.

In: Endocrinology, Vol. 102, No. 1, 1978, p. 16-23.

Research output: Contribution to journalArticle

Cunningham, GR, Tindall, DJ, Huckins, C & Means, AR 1978, 'Mechanisms for the testicular hypertrophy which follows hemicastration', Endocrinology, vol. 102, no. 1, pp. 16-23.
Cunningham GR, Tindall DJ, Huckins C, Means AR. Mechanisms for the testicular hypertrophy which follows hemicastration. Endocrinology. 1978;102(1):16-23.
Cunningham, G. R. ; Tindall, D. J. ; Huckins, C. ; Means, A. R. / Mechanisms for the testicular hypertrophy which follows hemicastration. In: Endocrinology. 1978 ; Vol. 102, No. 1. pp. 16-23.
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