Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods

Mark M. Mikhael, Paul M. Huddleston, Mark E. Zobitz, Quingshan Chen, Kristin D Zhao, Kai N. An

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.

Original languageEnglish (US)
Pages (from-to)2816-2820
Number of pages5
JournalJournal of Biomechanics
Volume41
Issue number13
DOIs
StatePublished - Sep 18 2008

Fingerprint

Strength of materials
Allografts
Bone
Bone and Bones
Processing
Tissue
Reconstructive Surgical Procedures
Mechanical Phenomena
Chemical Phenomena
Infectious Disease Transmission
Freeze Drying
Fracture energy
Axial compression
Fluid Therapy
Orthopedics
Strain energy
Cadaver
Surgery
Communicable Diseases
Compaction

Keywords

  • BioCleanse
  • Bone allograft
  • Chemical sterilization
  • Gamma irradiation
  • Mechanical strength

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods. / Mikhael, Mark M.; Huddleston, Paul M.; Zobitz, Mark E.; Chen, Quingshan; Zhao, Kristin D; An, Kai N.

In: Journal of Biomechanics, Vol. 41, No. 13, 18.09.2008, p. 2816-2820.

Research output: Contribution to journalArticle

Mikhael, Mark M. ; Huddleston, Paul M. ; Zobitz, Mark E. ; Chen, Quingshan ; Zhao, Kristin D ; An, Kai N. / Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods. In: Journal of Biomechanics. 2008 ; Vol. 41, No. 13. pp. 2816-2820.
@article{712f4b8b7fd34d1a8789f3d68763012b,
title = "Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods",
abstract = "Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse{\circledR} tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.",
keywords = "BioCleanse, Bone allograft, Chemical sterilization, Gamma irradiation, Mechanical strength",
author = "Mikhael, {Mark M.} and Huddleston, {Paul M.} and Zobitz, {Mark E.} and Quingshan Chen and Zhao, {Kristin D} and An, {Kai N.}",
year = "2008",
month = "9",
day = "18",
doi = "10.1016/j.jbiomech.2008.07.012",
language = "English (US)",
volume = "41",
pages = "2816--2820",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "13",

}

TY - JOUR

T1 - Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods

AU - Mikhael, Mark M.

AU - Huddleston, Paul M.

AU - Zobitz, Mark E.

AU - Chen, Quingshan

AU - Zhao, Kristin D

AU - An, Kai N.

PY - 2008/9/18

Y1 - 2008/9/18

N2 - Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.

AB - Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.

KW - BioCleanse

KW - Bone allograft

KW - Chemical sterilization

KW - Gamma irradiation

KW - Mechanical strength

UR - http://www.scopus.com/inward/record.url?scp=51049093782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51049093782&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2008.07.012

DO - 10.1016/j.jbiomech.2008.07.012

M3 - Article

C2 - 18760413

AN - SCOPUS:51049093782

VL - 41

SP - 2816

EP - 2820

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 13

ER -