Abstract
Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2816-2820 |
| Number of pages | 5 |
| Journal | Journal of Biomechanics |
| Volume | 41 |
| Issue number | 13 |
| DOIs | |
| State | Published - Sep 18 2008 |
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Keywords
- BioCleanse
- Bone allograft
- Chemical sterilization
- Gamma irradiation
- Mechanical strength
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods. / Mikhael, Mark M.; Huddleston, Paul M.; Zobitz, Mark E.; Chen, Quingshan; Zhao, Kristin D; An, Kai N.
In: Journal of Biomechanics, Vol. 41, No. 13, 18.09.2008, p. 2816-2820.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanical strength of bone allografts subjected to chemical sterilization and other terminal processing methods
AU - Mikhael, Mark M.
AU - Huddleston, Paul M.
AU - Zobitz, Mark E.
AU - Chen, Quingshan
AU - Zhao, Kristin D
AU - An, Kai N.
PY - 2008/9/18
Y1 - 2008/9/18
N2 - Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.
AB - Infectious disease transmission through the use of human donor allografts can be a catastrophic complication in an otherwise straightforward surgical procedure. The use of bone allograft in reconstructive orthopedic surgeries is increasing, yet severe complications, including death, can result if the transplanted tissues transmit a communicable disease to the tissue recipient. The BioCleanse® tissue sterilization process is a fully automated, low-temperature chemical sterilization process that renders allograft tissue sterile. The purpose of this study was to evaluate the effect of a chemical tissue sterilization process on the mechanical strength of cortical bone allografts prior to implantation. Cylindrical cortical bone specimens were harvested from seven human cadaver donors and treated either by: chemical sterilization alone; chemical sterilization and terminal sterilization by gamma irradiation; chemical sterilization, lyophilization, terminal sterilization by STERRAD and rehydration; or untreated. The specimens were tested to failure in axial compression, diametral compression, shear, or bending. There were no significant differences in ultimate stress, strain, or fracture energy between the chemically sterilized and control groups in any of the testing modes.
KW - BioCleanse
KW - Bone allograft
KW - Chemical sterilization
KW - Gamma irradiation
KW - Mechanical strength
UR - http://www.scopus.com/inward/record.url?scp=51049093782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51049093782&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2008.07.012
DO - 10.1016/j.jbiomech.2008.07.012
M3 - Article
C2 - 18760413
AN - SCOPUS:51049093782
VL - 41
SP - 2816
EP - 2820
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 13
ER -