TY - JOUR
T1 - Mechanical properties of respiratory muscles
AU - Sieck, Gary C.
AU - Ferreira, Leonardo F.
AU - Reid, Michael B.
AU - Mantilla, Carlos B.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of the upper airway.The basic structural and functional properties of respiratory muscles are similar to those of other striated muscles (both skeletal and cardiac).The sarcomere is the fundamental organizational unit of striated muscles and sarcomeric proteins underlie the passive and active mechanical properties of muscle fibers.In this respect,the functional categorization of different fiber types provides a conceptual framework to understand the physiological properties of respiratory muscles.Within the sarcomere, the interaction between the thick and thin filaments at the level of cross-bridges provides the elementary unit of force generation and contraction. Key to an understanding of the unique functional differences across muscle fiber types are differences in cross-bridge recruitment and cycling that relate to the expression of different myosin heavy chain isoforms in the thick filament. The active mechanical properties of muscle fibers are characterized by the relationship between myoplasmic Ca2+ and cross-bridge recruitment,force generation and sarcomere length (also cross-bridge recruitment), external load and shortening velocity (cross-bridge cycling rate),and cross-bridge cycling rate and ATP consumption. Passive mechanical properties are also important reflecting viscoelastic elements within sarcomeres as well as the extracellular matrix.Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes,but their manifestations will depend on their impact on these basic elemental structures.
AB - Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of the upper airway.The basic structural and functional properties of respiratory muscles are similar to those of other striated muscles (both skeletal and cardiac).The sarcomere is the fundamental organizational unit of striated muscles and sarcomeric proteins underlie the passive and active mechanical properties of muscle fibers.In this respect,the functional categorization of different fiber types provides a conceptual framework to understand the physiological properties of respiratory muscles.Within the sarcomere, the interaction between the thick and thin filaments at the level of cross-bridges provides the elementary unit of force generation and contraction. Key to an understanding of the unique functional differences across muscle fiber types are differences in cross-bridge recruitment and cycling that relate to the expression of different myosin heavy chain isoforms in the thick filament. The active mechanical properties of muscle fibers are characterized by the relationship between myoplasmic Ca2+ and cross-bridge recruitment,force generation and sarcomere length (also cross-bridge recruitment), external load and shortening velocity (cross-bridge cycling rate),and cross-bridge cycling rate and ATP consumption. Passive mechanical properties are also important reflecting viscoelastic elements within sarcomeres as well as the extracellular matrix.Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes,but their manifestations will depend on their impact on these basic elemental structures.
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U2 - 10.1002/cphy.c130003
DO - 10.1002/cphy.c130003
M3 - Article
C2 - 24265238
AN - SCOPUS:84893030004
SN - 2040-4603
VL - 3
SP - 1533
EP - 1567
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 4
ER -