Mechanical properties of normal and emphysematous canine lungs

S. S. Margulies, D. J. Tschumperlin

Research output: Contribution to journalArticle

Abstract

The right or left lung from 6 normal dogs (ME) and 6 dogs with chronic, bilateral papain-induced emphysema (E) were removed, degassed, and weighed. Transpulmonary pressure (P)-volume relationships were determined from 0 to 25cmH20 (TLC). At 10 cmH20, 3 alveolar capsules were attached. Isolated lungs were placed in a flow-type plethysmograph, and attached at a 3 way valve to positive end-expiratory pressure (PEEP), a constant flow air source, or a modified Harvard ventilator. After inflation to 20 cm HzO, lungs were deflated to 2.5, 5.0 or 7.5 cm HzO PEEP and ventilated sinusoidally at a fixed tidal volume (10%TLC) between 10 and 50 breaths/min. Capsule and bronchial pressures, and the volume and flow delivered to the bronchus were recorded on computer. End-expiratory volume (V) was determined from the P-volume relationships, and normalized compliance (C/V), airway resistance (Rair V), tissue resistance (Rtiss V), and hysteresivity (r|) were computed by linear regression between the P, volume and flow signals. E did not affect the frequency- or V-dependence of SHE c/v Mfv Rflu'v ; n Rtiss V, Rair V or C/V,Eof Rtiss V and Rair V increased, C/V decreased, but r| was not significantlyaffected. These data are consistent with the hypotheses that chronic papaininstillation decreases the airway-parenchymal interdependence, and increasesboth the elastic and viscous components of the lung, such that their ratio, n.,remains constant. This work was funded by The Whitaker Foundation.

Original languageEnglish (US)
Pages (from-to)A360
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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