Abstract
The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical issues of providing protection, maintaining a patent airway, and controlling swallowing and phonation, require that the regenerated laryngotracheal cartilages must have mechanical and material properties that closely mimic native tissue. These properties are determined by the cellular and proteomic characteristics of these tissues. However, little is known of these properties for these specific cartilages. This review considers what is known and what issues need to be addressed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 321-328 |
| Number of pages | 8 |
| Journal | Cartilage |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1 2019 |
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Keywords
- arytenoid
- cartilage
- corniculate
- cricoid
- cuneiform
- epiglottic
- larynx
- proteomic
- regenerative medicine
- thyroid
- tissue engineering
- trachea
ASJC Scopus subject areas
- Immunology and Allergy
- Biomedical Engineering
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Mechanical, Cellular, and Proteomic Properties of Laryngotracheal Cartilage. / Pauken, Christine M.; Heyes, Richard; Lott, David G.
In: Cartilage, Vol. 10, No. 3, 01.07.2019, p. 321-328.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mechanical, Cellular, and Proteomic Properties of Laryngotracheal Cartilage
AU - Pauken, Christine M.
AU - Heyes, Richard
AU - Lott, David G
PY - 2019/7/1
Y1 - 2019/7/1
N2 - The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical issues of providing protection, maintaining a patent airway, and controlling swallowing and phonation, require that the regenerated laryngotracheal cartilages must have mechanical and material properties that closely mimic native tissue. These properties are determined by the cellular and proteomic characteristics of these tissues. However, little is known of these properties for these specific cartilages. This review considers what is known and what issues need to be addressed.
AB - The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical issues of providing protection, maintaining a patent airway, and controlling swallowing and phonation, require that the regenerated laryngotracheal cartilages must have mechanical and material properties that closely mimic native tissue. These properties are determined by the cellular and proteomic characteristics of these tissues. However, little is known of these properties for these specific cartilages. This review considers what is known and what issues need to be addressed.
KW - arytenoid
KW - cartilage
KW - corniculate
KW - cricoid
KW - cuneiform
KW - epiglottic
KW - larynx
KW - proteomic
KW - regenerative medicine
KW - thyroid
KW - tissue engineering
KW - trachea
UR - http://www.scopus.com/inward/record.url?scp=85067596049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067596049&partnerID=8YFLogxK
U2 - 10.1177/1947603517749921
DO - 10.1177/1947603517749921
M3 - Review article
C2 - 29322878
AN - SCOPUS:85067596049
VL - 10
SP - 321
EP - 328
JO - Cartilage
JF - Cartilage
SN - 1947-6035
IS - 3
ER -