TY - JOUR
T1 - Mechanical and metabolic reflex activation of the sympathetic nervous system in younger adults with metabolic syndrome
AU - Limberg, Jacqueline
AU - Morgan, Barbara
AU - Schrage, William
N1 - Funding Information:
We thank Edward McKenna, Keelin O'Neil, Ann Bolgert, and Meghan Crain for technical assistance. We also thank Drs. John Dopp and Andrea Mason for equipment use. In addition, we would like to thank the involvement of the WNPRC Assay Services and the partial support from NIH grant RR000167 . This study was supported by the American Heart Association pre-doctoral awards # 0815622G (JKL) and 10PRE3870000 (JKL), the University of Wisconsin Madison Virginia Horne Henry Foundation (JKL, WGS), and grants HL105820 (WGS) and RR000167 (WGS) from the National Institutes of Health .
PY - 2014/7
Y1 - 2014/7
N2 - Aim: Based on reports of exaggerated blood pressure responses to whole-body exercise in patients with metabolic syndrome (MetSyn), we tested the hypothesis that MetSyn adults would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects. Methods: We studied 12 adults with MetSyn (34. ±. 3. years) and 12 healthy control subjects (34. ±. 3. years). Heart rate (HR; ECG), blood pressure (BP; finger photoplethysmography), and MSNA (microneurography of the peroneal nerve) were measured during: (1) static handgrip exercise at 15% of maximal voluntary contraction (MVC), and (2) static handgrip exercise at 30% MVC to fatigue, followed by post-exercise ischemia (PEI). Increases in MSNA, HR, and BP were assessed. Results: During static exercise at both 15 and 30% MVC, increases in MSNA, HR, and BP were not different between groups. MSNA remained significantly elevated from baseline during PEI and responses were not different between groups. Conclusion: Sympathetic and pressor responses to mechanoreflex and metaboreflex activation are not augmented in younger adults with MetSyn.
AB - Aim: Based on reports of exaggerated blood pressure responses to whole-body exercise in patients with metabolic syndrome (MetSyn), we tested the hypothesis that MetSyn adults would exhibit augmented sympathetic and pressor responses to mechanoreflex and metaboreflex activation when compared with healthy, age-matched control subjects. Methods: We studied 12 adults with MetSyn (34. ±. 3. years) and 12 healthy control subjects (34. ±. 3. years). Heart rate (HR; ECG), blood pressure (BP; finger photoplethysmography), and MSNA (microneurography of the peroneal nerve) were measured during: (1) static handgrip exercise at 15% of maximal voluntary contraction (MVC), and (2) static handgrip exercise at 30% MVC to fatigue, followed by post-exercise ischemia (PEI). Increases in MSNA, HR, and BP were assessed. Results: During static exercise at both 15 and 30% MVC, increases in MSNA, HR, and BP were not different between groups. MSNA remained significantly elevated from baseline during PEI and responses were not different between groups. Conclusion: Sympathetic and pressor responses to mechanoreflex and metaboreflex activation are not augmented in younger adults with MetSyn.
KW - Blood pressure
KW - Exercise pressor reflex
KW - MSNA
KW - Obesity
KW - Static exercise
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U2 - 10.1016/j.autneu.2014.03.003
DO - 10.1016/j.autneu.2014.03.003
M3 - Article
C2 - 24680829
AN - SCOPUS:84902373698
SN - 1566-0702
VL - 183
SP - 100
EP - 105
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
ER -