Meat-related mutagens and pancreatic cancer: Null results from a clinic-based case-control study

Rick J. Jansen, Dennis P. Robinson, Ryan D. Frank, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Ann L Oberg, Kari G. Rabe, Janet E Olson, Gloria M Petersen, Rashmi Sinha, Kristin E. Anderson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.

Original languageEnglish (US)
Pages (from-to)1336-1339
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Mutagens
Pancreatic Neoplasms
Meat
Case-Control Studies
National Cancer Institute (U.S.)
Age Factors
Diabetes Mellitus
Body Mass Index
Logistic Models
Smoking
Demography
Databases
Confidence Intervals
Food

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Jansen, R. J., Robinson, D. P., Frank, R. D., Stolzenberg-Solomon, R. Z., Bamlet, W. R., Oberg, A. L., ... Anderson, K. E. (2013). Meat-related mutagens and pancreatic cancer: Null results from a clinic-based case-control study. Cancer Epidemiology Biomarkers and Prevention, 22(7), 1336-1339. https://doi.org/10.1158/1055-9965.EPI-13-0343

Meat-related mutagens and pancreatic cancer : Null results from a clinic-based case-control study. / Jansen, Rick J.; Robinson, Dennis P.; Frank, Ryan D.; Stolzenberg-Solomon, Rachael Z.; Bamlet, William R.; Oberg, Ann L; Rabe, Kari G.; Olson, Janet E; Petersen, Gloria M; Sinha, Rashmi; Anderson, Kristin E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 7, 07.2013, p. 1336-1339.

Research output: Contribution to journalArticle

Jansen, RJ, Robinson, DP, Frank, RD, Stolzenberg-Solomon, RZ, Bamlet, WR, Oberg, AL, Rabe, KG, Olson, JE, Petersen, GM, Sinha, R & Anderson, KE 2013, 'Meat-related mutagens and pancreatic cancer: Null results from a clinic-based case-control study', Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 7, pp. 1336-1339. https://doi.org/10.1158/1055-9965.EPI-13-0343
Jansen, Rick J. ; Robinson, Dennis P. ; Frank, Ryan D. ; Stolzenberg-Solomon, Rachael Z. ; Bamlet, William R. ; Oberg, Ann L ; Rabe, Kari G. ; Olson, Janet E ; Petersen, Gloria M ; Sinha, Rashmi ; Anderson, Kristin E. / Meat-related mutagens and pancreatic cancer : Null results from a clinic-based case-control study. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 7. pp. 1336-1339.
@article{5419619eb7464e4480f19769549870bf,
title = "Meat-related mutagens and pancreatic cancer: Null results from a clinic-based case-control study",
abstract = "Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95{\%} confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.",
author = "Jansen, {Rick J.} and Robinson, {Dennis P.} and Frank, {Ryan D.} and Stolzenberg-Solomon, {Rachael Z.} and Bamlet, {William R.} and Oberg, {Ann L} and Rabe, {Kari G.} and Olson, {Janet E} and Petersen, {Gloria M} and Rashmi Sinha and Anderson, {Kristin E.}",
year = "2013",
month = "7",
doi = "10.1158/1055-9965.EPI-13-0343",
language = "English (US)",
volume = "22",
pages = "1336--1339",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "7",

}

TY - JOUR

T1 - Meat-related mutagens and pancreatic cancer

T2 - Null results from a clinic-based case-control study

AU - Jansen, Rick J.

AU - Robinson, Dennis P.

AU - Frank, Ryan D.

AU - Stolzenberg-Solomon, Rachael Z.

AU - Bamlet, William R.

AU - Oberg, Ann L

AU - Rabe, Kari G.

AU - Olson, Janet E

AU - Petersen, Gloria M

AU - Sinha, Rashmi

AU - Anderson, Kristin E.

PY - 2013/7

Y1 - 2013/7

N2 - Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.

AB - Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.

UR - http://www.scopus.com/inward/record.url?scp=84880000455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880000455&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-13-0343

DO - 10.1158/1055-9965.EPI-13-0343

M3 - Article

C2 - 23632817

AN - SCOPUS:84880000455

VL - 22

SP - 1336

EP - 1339

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 7

ER -