TY - JOUR
T1 - Meat-related mutagens and pancreatic cancer
T2 - Null results from a clinic-based case-control study
AU - Jansen, Rick J.
AU - Robinson, Dennis P.
AU - Frank, Ryan D.
AU - Stolzenberg-Solomon, Rachael Z.
AU - Bamlet, William R.
AU - Oberg, Ann L.
AU - Rabe, Kari G.
AU - Olson, Janet E.
AU - Petersen, Gloria M.
AU - Sinha, Rashmi
AU - Anderson, Kristin E.
PY - 2013/7
Y1 - 2013/7
N2 - Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.
AB - Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.
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U2 - 10.1158/1055-9965.EPI-13-0343
DO - 10.1158/1055-9965.EPI-13-0343
M3 - Article
C2 - 23632817
AN - SCOPUS:84880000455
SN - 1055-9965
VL - 22
SP - 1336
EP - 1339
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 7
ER -