Meat-related mutagens and pancreatic cancer: Null results from a clinic-based case-control study

Rick J. Jansen, Dennis P. Robinson, Ryan D. Frank, Rachael Z. Stolzenberg-Solomon, William R. Bamlet, Ann L. Oberg, Kari G. Rabe, Janet E. Olson, Gloria M. Petersen, Rashmi Sinha, Kristin E. Anderson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Pancreatic cancer is a devastating disease for which the role of dietary factors remains inconclusive. The study objective was to evaluate risk of pancreatic cancer associated with meat preparation methods and meat-related mutagen consumption using a clinic-based case-control design. Methods: There were 384 cases and 983 controls; subjects provided demographic information and completed a 144-item food frequency questionnaire, which was used to estimate meat mutagen intake using the National Cancer Institute's CHARRED database (Bethesda, MD). Logistic regression was used to calculate ORs and 95% confidence intervals (CI), adjusted for factors including age, sex, cigarette smoking, body mass index, and diabetes mellitus. Results: Overall, the findings were null with respect to meat mutagen intake and pancreatic cancer. Conclusions: The results do not support an association between well-done meat or meat-related mutagen intake and pancreatic cancer and contrast with generally increased risks reported in previous studies. Impact: These data contribute to evidence about pancreatic cancer and potentially carcinogenic compounds in meat.

Original languageEnglish (US)
Pages (from-to)1336-1339
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number7
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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