TY - JOUR
T1 - Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma
T2 - Results from a NCI-SEER case-control study
AU - Cross, Amanda J.
AU - Ward, Mary H.
AU - Schenk, Mary Jean
AU - Kulldorff, Martin
AU - Cozen, Wendy
AU - Davis, Scott
AU - Colt, Joanne S.
AU - Hartge, Patricia
AU - Cerhan, James R.
AU - Sinha, Rashmi
N1 - Funding Information:
The authors gratefully acknowledge the contributions of the study participants; the SEER centers of Iowa, Los Angeles, Detroit and Seattle for rapid identification of cases; the Centers for Medicare and Medicaid Services (CMS) for selection of older controls; Carol Haines (Westat) for development of study materials and procedures, for selection of younger controls and for study coordination; Steve Palladino and Jane Curtin (IMS) for computer support; Carla Chorley (BBI Biotech Research Laboratories) for specimen handling; and Geoffrey Tobias for research assistance. Support for this study included the following contracts with the National Cancer Institute: N01-PC-67010, N01-PC-67008, N02-PC-71105, N01-PC-67009 and N01-PC-65064. This research was supported [in part] by the Intramural Research Program of the National Cancer Institute of the National Institutes of Health.
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Non-Hodgkin Lymphoma (NHL) incidence has risen dramatically over past decades, but the reasons for most of this increase are not known. Meat cooked well-done using high-temperature cooking techniques produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P). This study was conducted as a population-based case-control study in Iowa, Detroit, Seattle and Los Angeles and was designed to determine whether meat, meat-cooking methods, HCAs or PAHs from meat were associated with NHL risk. This study consisted of 458 NHL cases, diagnosed between 1998 and 2000, and 383 controls. Participants completed a 117-item food frequency questionnaire (FFQ), with graphical aids to assess the meat-cooking method and doneness level, which was linked to a HCA and B[a]P database. Logistic regression, comparing the fourth to the first quartile, found no association between red meat or processed meat intake and risk for NHL [odds ratio (OR) and 95% confidence interval (CI): 1.10 (0.67-1.81) and 1.18 (0.74-1.89), respectively]. A marginally significant elevated risk for NHL was associated with broiled meat [OR and 95% CI: 1.32 (0.99-1.77); P trend = 0.09], comparing those who consumed broiled meat with those who did not. The degree to which meat was cooked was not associated with the risk for NHL, although one of the HCAs, DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), was associated with an inverse risk. Fat intake was associated with a significantly elevated risk for NHL [OR and 95% CI: 1.60 (1.05-2.45); P trend = 0.12]; in contrast, animal protein was inversely associated with risk for NHL [OR and 95% CI: 0.39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL.
AB - Non-Hodgkin Lymphoma (NHL) incidence has risen dramatically over past decades, but the reasons for most of this increase are not known. Meat cooked well-done using high-temperature cooking techniques produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P). This study was conducted as a population-based case-control study in Iowa, Detroit, Seattle and Los Angeles and was designed to determine whether meat, meat-cooking methods, HCAs or PAHs from meat were associated with NHL risk. This study consisted of 458 NHL cases, diagnosed between 1998 and 2000, and 383 controls. Participants completed a 117-item food frequency questionnaire (FFQ), with graphical aids to assess the meat-cooking method and doneness level, which was linked to a HCA and B[a]P database. Logistic regression, comparing the fourth to the first quartile, found no association between red meat or processed meat intake and risk for NHL [odds ratio (OR) and 95% confidence interval (CI): 1.10 (0.67-1.81) and 1.18 (0.74-1.89), respectively]. A marginally significant elevated risk for NHL was associated with broiled meat [OR and 95% CI: 1.32 (0.99-1.77); P trend = 0.09], comparing those who consumed broiled meat with those who did not. The degree to which meat was cooked was not associated with the risk for NHL, although one of the HCAs, DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), was associated with an inverse risk. Fat intake was associated with a significantly elevated risk for NHL [OR and 95% CI: 1.60 (1.05-2.45); P trend = 0.12]; in contrast, animal protein was inversely associated with risk for NHL [OR and 95% CI: 0.39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL.
UR - http://www.scopus.com/inward/record.url?scp=31544473118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=31544473118&partnerID=8YFLogxK
U2 - 10.1093/carcin/bgi212
DO - 10.1093/carcin/bgi212
M3 - Article
C2 - 16113054
AN - SCOPUS:31544473118
SN - 0143-3334
VL - 27
SP - 293
EP - 297
JO - Carcinogenesis
JF - Carcinogenesis
IS - 2
ER -