@article{21b25cdbdedc4eff9251e27befc06e95,
title = "Measurements of adiposity as prognostic biomarkers for survival with anti-angiogenic treatment in epithelial ovarian cancer: An NRG Oncology/Gynecologic Oncology Group ancillary data analysis of GOG 218",
abstract = "Objective: Adiposity has been hypothesized to interfere with the activity of bevacizumab (BEV), an anti-angiogenic agent. Measurements of adiposity, BMI, surface fat area (SFA), and visceral fat area (VFA) were investigated as prognostic of oncologic outcomes among patients treated with chemotherapy, with or without BEV, on GOG 218, a prospective phase III trial. Method: Pretreatment computed tomography (CT) for 1538 GOG 218 participants were analyzed. Proportional hazards models assessed association between adiposity and overall survival (OS) adjusted for other prognostic factors. The predictive value of adiposity as a function of BEV treatment was assessed in 1019 patients randomized to either chemotherapy (CT) + placebo (P) → P or CT + BEV → BEV. Results: After adjusting for prognostic factors, SFA was not associated with the overall hazard of death (p = 0.981). There was a non-significant 0.1% (p = 0.062) increase in hazard of death associated with a unit increase in VFA. When comparing the treatment HRs for patients who did and did not receive BEV, there was no association with SFA (p = 0.890) or VFA (p = 0.106). A non-significant 0.8% increase in the hazard of death with unit increase in BMI (p = 0.086) was observed. BMI values were not predictive of a longer survival for patients with BEV vs placebo (p = 0.606). Conclusion: Measures of adiposity strongly correlated to one another but were not predictive of efficacy for BEV. VFA is a weak prognostic factor.",
keywords = "Adiposity, Epithelial ovarian cancer, NRG, Prognostic biomarkers",
author = "Wade, {K. N.Slaughter} and Brady, {M. F.} and T. Thai and Y. Wang and B. Zheng and R. Salani and Tewari, {K. S.} and Gray, {H. J.} and Bakkum-Gamez, {J. N.} and Burger, {R. A.} and Moore, {K. N.} and Bookman, {M. A.}",
note = "Funding Information: This study was supported by National Cancer Institute grants NRG Oncology SDMC grant U10CA180822 , UG1CA189867 (NCORP) and the NRG Oncology Operations grant U10CA180868 . The clinical trial upon which this manuscript is based was sponsored by the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI), under the Collaborative Research and Development Agreement (CRADA) for BEV between NCI and Genentech, Inc. Funding Information: This study was supported by National Cancer Institute grants NRG Oncology SDMC grant U10CA180822, UG1CA189867 (NCORP) and the NRG Oncology Operations grant U10CA180868. The clinical trial upon which this manuscript is based was sponsored by the Cancer Therapy Evaluation Program (CTEP) of the National Cancer Institute (NCI), under the Collaborative Research and Development Agreement (CRADA) for BEV between NCI and Genentech, Inc. The following NRG Oncology/Gynecologic Oncology Group member institutions participated in the primary treatment studies: Cancer Trials Support Unit, University of Oklahoma Health Sciences Center, Ohio State University Comprehensive Cancer Center, University of California Medical Center At Irvine-Orange Campus, Abramson Cancer Center of The University of Pennsylvania, Mayo Clinic, Walter Reed National Military Medical Center, Saitama Medical University International Medical Center, Gynecologic Oncology Network/Brody School of Medicine, University of Alabama at Birmingham, Rush University Medical Center, University of Kentucky, University of Iowa Hospitals and Clinics, Fred Hutchinson Cancer Research Center, University of Chicago, Yale University, Metro-Minnesota CCOP, Duke University Medical Center, Cleveland Clinic Foundation, Washington University School of Medicine, Women's Cancer Center of Nevada, University of Mississippi Medical Center, Fox Chase Cancer Center, University of North Carolina at Chapel Hill, Cooper Hospital University Medical Center, University of Hawaii, Indiana University Hospital/Melvin and Bren Simon Cancer Center, Seoul National University Hospital, The Hospital of Central Connecticut, Roswell Park Cancer Institute, Abington Memorial Hospital, Mount Sinai School of Medicine, Northwestern University, Women and Infants Hospital, University of Colorado Cancer Center - Anschutz Cancer Pavilion, University of California at Los Angeles Health System, Wake Forest University Health Sciences, University of New Mexico, Stony Brook University Medical Center, University of Virginia, Case Western Reserve University, Fletcher Allen Health Care, Georgia Center for Oncology Research and Education (CORE), Cancer Research for the Ozarks NCORP, Wayne State University/Karmanos Cancer Institute, University of Minnesota Medical Center-Fairview, Northern Indiana Cancer Research Consortium, Tufts-New England Medical Center, University of Pittsburgh Cancer Institute (UPCI), State University of New York Downstate Medical Center, M D Anderson Cancer Center, Moffitt Cancer Center and Research Institute, University of Wisconsin Hospital and Clinics, University of Texas ? Galveston, Gynecologic Oncology of West Michigan PLLC, Carle Cancer Center, Cancer Research Consortium of West Michigan NCORP, Central Illinois CCOP, Virginia Commonwealth University, Saint Vincent Hospital, Penn State Milton S Hershey Medical Center, New York University Medical Center, Michigan Cancer Research Consortium Community Clinical Oncology Program, Northern New Jersey CCOP, University of Cincinnati, Memorial Sloan Kettering Cancer Center, University of Massachusetts Memorial Health Care, Aurora Women's Pavilion of Aurora West Allis Medical Center, Kansas City CCOP, Wisconsin NCI Community Oncology Research Program, Missouri Valley Cancer Consortium CCOP, Delaware/Christiana Care CCOP, William Beaumont Hospital, Saint Louis-Cape Girardeau CCOP, and Wichita CCOP. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
doi = "10.1016/j.ygyno.2019.07.020",
language = "English (US)",
volume = "155",
pages = "69--74",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "1",
}