@article{d32d7174102742d8b1b892794868b3c5,
title = "Measurement of murine serum amyloid P component by rate nephelometry",
abstract = "Murine serum amyloid P component (SAP) is an acute-phase protein that is increased 2-10-fold in concentration following appropriate inflammatory or infections stimuli. Previous studies of the acute-phase SAP response have employed quantitative immunoelectrophoresis or radioimmunoassay to measure SAP concentration. A rate nephelometric procedure has been developed which measures SAP concentration rapidly and with equivalent or greater precision than the previously applied techniques. This simple method will facilitate experimental and clinical studies of the acute-phase response.",
keywords = "acute-phase response, nephelometry, serum amyloid P (SAP)",
author = "Gertz, {Morie A.} and Sipe, {Jean D.} and Martha Skinner and Cohen, {Alan S.} and Kyle, {Robert A.}",
note = "Funding Information: After tissue injury and cellular death, 2 processes are set into motion. The first, inflammation, is localized and is concerned with limiting the injury and repairing the damage. The second response is systemic and is called the acute-phase response. This response is characterized by an increase in hepatic synthesis of a variety of plasma proteins termed acute-phase reactants (Kushner et al., 1981). The exact biological role of the acute-phase response is poorly defined, but is thought to be of importance in host restitution. In humans, C-reactive protein (CRP) is one of the most easily measured acute-phase proteins and has been used clinically to monitor 1 Supported by grants from U.S. Pubfic Health Service, National Institute of Arthritis, Metabolism and Digestive Diseases (AM 04599 and AM 07014), from the General Clinical Research Centers Branch of the Division of Research Resources, National Institutes of Health (RR 533), Multipurpose Arthritis Center, National Institutes of Health (AM 20613 and CA 16835), the Arthritis Foundation and the Kroc Foundation. 2 Address reprint requests to Dr. Jean D. Sipe, Arthritis Section, K-5, Boston University School of Medicine, 71 East Concord Street, Boston, MA 02118, U.S.A.",
year = "1984",
month = apr,
day = "27",
doi = "10.1016/0022-1759(84)90315-6",
language = "English (US)",
volume = "69",
pages = "173--180",
journal = "Journal of Immunological Methods",
issn = "0022-1759",
publisher = "Elsevier",
number = "2",
}