Measurement of mechanical properties of homogeneous tissue with ultrasonically induced shear waves

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Fundamental mechanical properties of tissue are altered by many diseases. Regional and systemic diseases can cause changes in tissue properties. Liver stiffness is caused by cirrhosis and fibrosis. Vascular wall stiffness and tone are altered by smoking, diabetes and other diseases. Measurement of tissue mechanical properties has historically been done with palpation. However palpation is subjective, relative, and not quantitative or reproducible. Elastography in which strain is measured due to stress application gives a qualitative estimate of Young's modulus at low frequency. We have developed a method that takes advantage of the fact that the wave equation is local and shear wave propagation depends only on storage and loss moduli in addition to density, which does not vary much in soft tissues. Our method is called shearwave dispersion ultrasonic velocity measurement (SDUV). The method uses ultrasonic radiation force to produce repeated motion in tissue that induces shear waves to propagate. The shear wave propagation speed is measured with pulse echo ultrasound as a function of frequency of the shear wave. The resulting velocity dispersion curve is fit with a Voight model to determine the elastic and viscous moduli of the tissue. Results indicate accurate and precise measurements are possible using this "noninvasive biopsy" method. Measurements in beef along and across the fibers are consistent with the literature values.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationUltrasonic Imaging and Signal Processing
DOIs
StatePublished - Oct 15 2007
EventMedical Imaging 2007: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 18 2007Feb 19 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6513
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2007: Ultrasonic Imaging and Signal Processing
CountryUnited States
CitySan Diego, CA
Period2/18/072/19/07

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Greenleaf, J. F., & Chen, S. (2007). Measurement of mechanical properties of homogeneous tissue with ultrasonically induced shear waves. In Medical Imaging 2007: Ultrasonic Imaging and Signal Processing [65130F] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6513). https://doi.org/10.1117/12.706804