TY - JOUR
T1 - Measurement of in vivo myocardial microcirculatory function with electron beam CT
AU - Lerman, Lilach O.
AU - Siripornpitak, Suvipaporn
AU - Maffei, Natalia Luna
AU - Sheedy, Patrick F.
AU - Ritman, Erik L.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Purpose: The purpose of this work was to examine the capability of electron beam CT (EBCT) to characterize responses of recruitable (capillaries and small arterioles) compared with nonrecruitable (small to large arterioles) myocardial microvessels to vasoactive substances. Method: Myocardial perfusion (F) and total intramyocardial blood volume (BV) of the anterior cardiac wall were quantitated in 36 pigs, using EBCT and intravenous contrast agent injections, before and after intracoronary administration of either NG-monomethyl-L-arginine (L-NMMA), nitroglycerin, adenosine, or saline. Plotting the relationship of BV and F provided values for the recruitable and nonrecruitable microvascular transit times and BV allotment. Results: Nitroglycerin increased nonrecruitable BV by 84.5 ± 7.4%, whereas adenosine increased both recruitable and nonrecruitable microvascular BV (47.1 ± 18.9 and 66.0 ± 10.9%, respectively). L-NMMA led to a 25.1% decrease only in the recruitable BV. In the control group, no changes were observed. Conclusion: Characteristic responses of different-size myocardial microvessels may be inferred with EBCT, which provides a unique opportunity to portray intramyocardial microcirculatory function noninvasively.
AB - Purpose: The purpose of this work was to examine the capability of electron beam CT (EBCT) to characterize responses of recruitable (capillaries and small arterioles) compared with nonrecruitable (small to large arterioles) myocardial microvessels to vasoactive substances. Method: Myocardial perfusion (F) and total intramyocardial blood volume (BV) of the anterior cardiac wall were quantitated in 36 pigs, using EBCT and intravenous contrast agent injections, before and after intracoronary administration of either NG-monomethyl-L-arginine (L-NMMA), nitroglycerin, adenosine, or saline. Plotting the relationship of BV and F provided values for the recruitable and nonrecruitable microvascular transit times and BV allotment. Results: Nitroglycerin increased nonrecruitable BV by 84.5 ± 7.4%, whereas adenosine increased both recruitable and nonrecruitable microvascular BV (47.1 ± 18.9 and 66.0 ± 10.9%, respectively). L-NMMA led to a 25.1% decrease only in the recruitable BV. In the control group, no changes were observed. Conclusion: Characteristic responses of different-size myocardial microvessels may be inferred with EBCT, which provides a unique opportunity to portray intramyocardial microcirculatory function noninvasively.
KW - Computed tomography, techniques
KW - Microcirculation
KW - Myocardium
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U2 - 10.1097/00004728-199905000-00013
DO - 10.1097/00004728-199905000-00013
M3 - Article
C2 - 10348445
AN - SCOPUS:0032906697
SN - 0363-8715
VL - 23
SP - 390
EP - 398
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 3
ER -