Measles virus V protein inhibits p53 family member p73

Cristian D. Cruz, Heidi Palosaari, Jean Patrick Parisien, Patricia Devaux, Roberto Cattaneo, Toru Ouchi, Curt M. Horvath

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Paramyxovirus V proteins function as host interference factors that inactivate antiviral responses, including interferon. Characterization of cellular proteins that copurify with ectopically expressed measles virus V protein has revealed interactions with DNA binding domains of p53 family proteins, p53 and p73. Specific transcriptional assays reveal that expression of measles virus V cDNA inhibits p73, but not p53. Expression of measles virus V cDNA can delay cell death induced by genotoxic stress and also can decrease the abundance of the proapoptotic factor PUMA, a p73 target. Recombinant measles virus with an engineered deficiency in V protein is capable of inducing more severe cytopathic effects than the wild type, implicating measles virus V protein as an inhibitor of cell death. These findings also suggest that p73-PUMA signaling may be a previously unrecognized arm of cellular innate antiviral immunity.

Original languageEnglish (US)
Pages (from-to)5644-5650
Number of pages7
JournalJournal of Virology
Volume80
Issue number11
DOIs
StatePublished - Jun 2006

Fingerprint

Measles virus
Antiviral Agents
Cell Death
Complementary DNA
proteins
Innate Immunity
Cellular Immunity
Interferons
DNA Damage
cell death
Proteins
Respirovirus
cytopathogenicity
DNA-binding domains
DNA
interferons
crossover interference
measles virus V protein
immunity
assays

ASJC Scopus subject areas

  • Immunology

Cite this

Cruz, C. D., Palosaari, H., Parisien, J. P., Devaux, P., Cattaneo, R., Ouchi, T., & Horvath, C. M. (2006). Measles virus V protein inhibits p53 family member p73. Journal of Virology, 80(11), 5644-5650. https://doi.org/10.1128/JVI.02400-05

Measles virus V protein inhibits p53 family member p73. / Cruz, Cristian D.; Palosaari, Heidi; Parisien, Jean Patrick; Devaux, Patricia; Cattaneo, Roberto; Ouchi, Toru; Horvath, Curt M.

In: Journal of Virology, Vol. 80, No. 11, 06.2006, p. 5644-5650.

Research output: Contribution to journalArticle

Cruz, CD, Palosaari, H, Parisien, JP, Devaux, P, Cattaneo, R, Ouchi, T & Horvath, CM 2006, 'Measles virus V protein inhibits p53 family member p73', Journal of Virology, vol. 80, no. 11, pp. 5644-5650. https://doi.org/10.1128/JVI.02400-05
Cruz, Cristian D. ; Palosaari, Heidi ; Parisien, Jean Patrick ; Devaux, Patricia ; Cattaneo, Roberto ; Ouchi, Toru ; Horvath, Curt M. / Measles virus V protein inhibits p53 family member p73. In: Journal of Virology. 2006 ; Vol. 80, No. 11. pp. 5644-5650.
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