Measles virus glycoprotein complex assembly, receptor attachment, and cell entry

C. K. Navaratnarajah, V. H J Leonard, Roberto Cattaneo

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Measles virus (MV) enters cells by membrane fusion at the cell surface at neutral pH. Two glycoproteins mediate this process: the hemagglutinin (H) and fusion (F) proteins. The H-protein binds to receptors, while the F-protein mediates fusion of the viral and cellular membranes. H naturally interacts with at least three different receptors. The wild-type virus primarily uses the signaling lymphocyte activation molecule (SLAM, CD150) expressed on certain lymphatic cells, while the vaccine strain has gained the ability to also use the ubiquitous membrane cofactor protein (MCP, CD46), a regulator of complement activation. Additionally, MV infects polarized epithelial cells through an unidentified receptor (EpR). The footprints of the three receptors on H have been characterized, and the focus of research is shifting to the characterization of receptor-specific conformational changes that occur in the H-protein dimer and how these are transmitted to the F-protein trimer. It was also shown that MV attachment and cell entry can be readily targeted to designated receptors by adding specificity determinants to the H-protein. These studies have contributed to our understanding of membrane fusion by the glycopro-tein complex of paramyxoviruses in general.

Original languageEnglish (US)
Pages (from-to)59-76
Number of pages18
JournalCurrent Topics in Microbiology and Immunology
Volume329
DOIs
StatePublished - 2009

Fingerprint

Measles virus
Glycoproteins
Proteins
Membrane Fusion
CD46 Antigens
Virus Attachment
Virus Internalization
Cell Fusion
Complement Activation
Hemagglutinins
Lymphocyte Activation
Vaccines
Epithelial Cells
Cell Membrane
Viruses
Research

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Measles virus glycoprotein complex assembly, receptor attachment, and cell entry. / Navaratnarajah, C. K.; Leonard, V. H J; Cattaneo, Roberto.

In: Current Topics in Microbiology and Immunology, Vol. 329, 2009, p. 59-76.

Research output: Contribution to journalArticle

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