Measles virus editing provides an additional cysteine-rich protein

Roberto Cattaneo, Karin Kaelin, Knut Baczko, Martin A. Billeter

Research output: Contribution to journalArticle

245 Scopus citations

Abstract

The measles virus (MV) phosphoprotein (P) gene encodes two known proteins, P (Mr ≈ 70,000), involved in viral transcription, and, in a different reading frame, C (Mr ≈ 20,000). By a combination of cDNA cloning, cDNA and RNA sequencing, and in vitro translation, we demonstrate here that the MV P gene also expresses a third product (Mr ≈ 46,000) containing the amino-terminal region of P but a different, cysteinerich carboxy-terminal motif. This third protein is translated from mRNAs in which one G residue has been inserted after three genomically encoded Gs, a modification found in about 50% of the P mRNAs. A smaller fraction of transcripts contain several additional G residues.

Original languageEnglish (US)
Pages (from-to)759-764
Number of pages6
JournalCell
Volume56
Issue number5
DOIs
StatePublished - Mar 10 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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