Meal fat storage in subcutaneous adipose tissue: Comparison of pioglitazone and glipizide treatment of type 2 diabetes

Ananda Basu, Rita Basu, Vishwanath Pattan, Robert A. Rizza, Michael D. Jensen

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Treatment of type 2 diabetes (T2DM) with pioglitazone changes abdominal fat in the opposite direction as treatment with glipizide. To determine whether these two medications affect adipose tissue meal fatty acid storage differently we studied 19 T2DM treated with either pioglitazone (n = 8) or glipizide (n = 11) and 11 non-DM control subjects matched for age, BMI, abdominal and leg fat. A breakfast mixed meal containing 1-14Ctriolein was given and abdominal and femoral subcutaneous (sc) adipose tissue biopsies were collected 6 and 24 h later to measure meal fatty acid storage. The portion of meal fatty acids stored in upper body sc and lower body sc adipose tissue did not differ between non-DM and T2DM subjects either at 6 or 24 h. Likewise, meal fatty acid storage did not differ between the T2DM participants treated with pioglitazone or glipizide. We conclude that meal fatty acid storage in upper body and lower body sc adipose tissue is not abnormal in T2DM patients treated with pioglitazone or glipizide.

Original languageEnglish (US)
Pages (from-to)2058-2060
Number of pages3
JournalObesity
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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