MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients

Ingrid Masson, Martin Flamant, Nicolas Maillard, Andrew D Rule, François Vrtovsnik, Marie Noëlle Peraldi, Lise Thibaudin, Etienne Cavalier, Emmanuelle Vidal-Petiot, Christine Bonneau, Olivier Moranne, Eric Alamartine, Christophe Mariat, Pierre Delanaye

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Abstract

BACKGROUND: The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. METHODS: We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30% of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). RESULTS: Mean measured GFR (mGFR) was 50±19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80% and 74% for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR <60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR >90 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. CONCLUSIONS: The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages.

Original languageEnglish (US)
Pages (from-to)1211-1217
Number of pages7
JournalTransplantation
Volume95
Issue number10
DOIs
StatePublished - May 27 2013

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Diet Therapy
Glomerular Filtration Rate
Chronic Renal Insufficiency
Epidemiology
Kidney
Creatinine
Transplant Recipients
Inulin
Edetic Acid
Transplants

Keywords

  • CKD-EPI
  • Glomerular filtration rate
  • Renal transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Masson, I., Flamant, M., Maillard, N., Rule, A. D., Vrtovsnik, F., Peraldi, M. N., ... Delanaye, P. (2013). MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients. Transplantation, 95(10), 1211-1217. https://doi.org/10.1097/TP.0b013e318288caa6

MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients. / Masson, Ingrid; Flamant, Martin; Maillard, Nicolas; Rule, Andrew D; Vrtovsnik, François; Peraldi, Marie Noëlle; Thibaudin, Lise; Cavalier, Etienne; Vidal-Petiot, Emmanuelle; Bonneau, Christine; Moranne, Olivier; Alamartine, Eric; Mariat, Christophe; Delanaye, Pierre.

In: Transplantation, Vol. 95, No. 10, 27.05.2013, p. 1211-1217.

Research output: Contribution to journalArticle

Masson, I, Flamant, M, Maillard, N, Rule, AD, Vrtovsnik, F, Peraldi, MN, Thibaudin, L, Cavalier, E, Vidal-Petiot, E, Bonneau, C, Moranne, O, Alamartine, E, Mariat, C & Delanaye, P 2013, 'MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients', Transplantation, vol. 95, no. 10, pp. 1211-1217. https://doi.org/10.1097/TP.0b013e318288caa6
Masson, Ingrid ; Flamant, Martin ; Maillard, Nicolas ; Rule, Andrew D ; Vrtovsnik, François ; Peraldi, Marie Noëlle ; Thibaudin, Lise ; Cavalier, Etienne ; Vidal-Petiot, Emmanuelle ; Bonneau, Christine ; Moranne, Olivier ; Alamartine, Eric ; Mariat, Christophe ; Delanaye, Pierre. / MDRD versus CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients. In: Transplantation. 2013 ; Vol. 95, No. 10. pp. 1211-1217.
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abstract = "BACKGROUND: The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. METHODS: We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30{\%} of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). RESULTS: Mean measured GFR (mGFR) was 50±19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80{\%} and 74{\%} for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR <60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR >90 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. CONCLUSIONS: The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages.",
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AU - Masson, Ingrid

AU - Flamant, Martin

AU - Maillard, Nicolas

AU - Rule, Andrew D

AU - Vrtovsnik, François

AU - Peraldi, Marie Noëlle

AU - Thibaudin, Lise

AU - Cavalier, Etienne

AU - Vidal-Petiot, Emmanuelle

AU - Bonneau, Christine

AU - Moranne, Olivier

AU - Alamartine, Eric

AU - Mariat, Christophe

AU - Delanaye, Pierre

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N2 - BACKGROUND: The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. METHODS: We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30% of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). RESULTS: Mean measured GFR (mGFR) was 50±19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80% and 74% for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR <60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR >90 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. CONCLUSIONS: The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages.

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KW - CKD-EPI

KW - Glomerular filtration rate

KW - Renal transplantation

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