Mayo Cognitive Factor Scales: Distinguishing Normal and Clinical Samples by Profile Variability

Robert J. Ivnik, Glenn E. Smith, James F. Malec, Emre Kokmen, Eric G. Tangalos

Research output: Contribution to journalArticle

8 Scopus citations


This study examined a central tenet in clinical neuropsychology: Cognitive test variability is a useful index of neurologic status. B.S. Plake, C.R. Reynolds, and T.B. Gutkin's (1981) Profile Variability Index (PVI) was applied to Mayo Cognitive Factor Scales (MCFS) scores to index overall variability among these aggregate measures of primary cognitive constructs. Mean PVIs were statistically greater among neurologically suspect than among normal older persons; however, logistic regression and sensitivity/specificity analyses demonstrated that PVIs had limited predictive value. These same analyses showed that when selected MCFS scores and education were considered together, strong diagnostic sensitivity (82%) and specificity (89%) were achieved, therein validating the newly introduced MCFS and supporting their future application in clinical and research settings.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
Issue number2
StatePublished - Apr 1994


ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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