Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN

Sanjeev M Sethi, Mark Haas, Glen S. Markowitz, Vivette D. D'Agati, Helmut G. Rennke, J. Charles Jennette, Ingeborg M. Bajema, Charles E. Alpers, Anthony Chang, Lynn D. Cornell, Fernando G Cosio, Agnes B. Fogo, Richard J. Glassock, Sundaram Hariharan, Neeraja Kambham, Donna J. Lager, Nelson Leung, Michael Mengel, Karl A Nath, Ian S. Roberts & 15 others Brad H. Rovin, Surya V. Seshan, Richard J.H. Smith, Patrick D. Walker, Christopher G. Winearls, Gerald B. Appel, Mariam P Alexander, Daniel C. Cattran, Carmen Avila Casado, H. Terence Cook, An S. De Vriese, Jai Radhakrishnan, Lorraine C. Racusen, Pierre Ronco, Fernando Custodio Fervenza

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aimof standardizing the kidney biopsy report ofGN.On the basis of etiology/ pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basementmembraneGN,monoclonal IgGN, andC3glomerulopathy.The pathogenesisbased classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

Original languageEnglish (US)
Pages (from-to)1278-1287
Number of pages10
JournalJournal of the American Society of Nephrology
Volume27
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Pathology
Kidney
Immune Complex Diseases
Guidelines
Biopsy
Antineutrophil Cytoplasmic Antibodies
Lupus Nephritis
Fluorescence Microscopy
Immunoglobulin A
Microscopy
Electron Microscopy
Light
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology

Cite this

Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN. / Sethi, Sanjeev M; Haas, Mark; Markowitz, Glen S.; D'Agati, Vivette D.; Rennke, Helmut G.; Jennette, J. Charles; Bajema, Ingeborg M.; Alpers, Charles E.; Chang, Anthony; Cornell, Lynn D.; Cosio, Fernando G; Fogo, Agnes B.; Glassock, Richard J.; Hariharan, Sundaram; Kambham, Neeraja; Lager, Donna J.; Leung, Nelson; Mengel, Michael; Nath, Karl A; Roberts, Ian S.; Rovin, Brad H.; Seshan, Surya V.; Smith, Richard J.H.; Walker, Patrick D.; Winearls, Christopher G.; Appel, Gerald B.; Alexander, Mariam P; Cattran, Daniel C.; Casado, Carmen Avila; Cook, H. Terence; De Vriese, An S.; Radhakrishnan, Jai; Racusen, Lorraine C.; Ronco, Pierre; Fervenza, Fernando Custodio.

In: Journal of the American Society of Nephrology, Vol. 27, No. 5, 01.05.2016, p. 1278-1287.

Research output: Contribution to journalArticle

Sethi, SM, Haas, M, Markowitz, GS, D'Agati, VD, Rennke, HG, Jennette, JC, Bajema, IM, Alpers, CE, Chang, A, Cornell, LD, Cosio, FG, Fogo, AB, Glassock, RJ, Hariharan, S, Kambham, N, Lager, DJ, Leung, N, Mengel, M, Nath, KA, Roberts, IS, Rovin, BH, Seshan, SV, Smith, RJH, Walker, PD, Winearls, CG, Appel, GB, Alexander, MP, Cattran, DC, Casado, CA, Cook, HT, De Vriese, AS, Radhakrishnan, J, Racusen, LC, Ronco, P & Fervenza, FC 2016, 'Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN', Journal of the American Society of Nephrology, vol. 27, no. 5, pp. 1278-1287. https://doi.org/10.1681/ASN.2015060612
Sethi, Sanjeev M ; Haas, Mark ; Markowitz, Glen S. ; D'Agati, Vivette D. ; Rennke, Helmut G. ; Jennette, J. Charles ; Bajema, Ingeborg M. ; Alpers, Charles E. ; Chang, Anthony ; Cornell, Lynn D. ; Cosio, Fernando G ; Fogo, Agnes B. ; Glassock, Richard J. ; Hariharan, Sundaram ; Kambham, Neeraja ; Lager, Donna J. ; Leung, Nelson ; Mengel, Michael ; Nath, Karl A ; Roberts, Ian S. ; Rovin, Brad H. ; Seshan, Surya V. ; Smith, Richard J.H. ; Walker, Patrick D. ; Winearls, Christopher G. ; Appel, Gerald B. ; Alexander, Mariam P ; Cattran, Daniel C. ; Casado, Carmen Avila ; Cook, H. Terence ; De Vriese, An S. ; Radhakrishnan, Jai ; Racusen, Lorraine C. ; Ronco, Pierre ; Fervenza, Fernando Custodio. / Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN. In: Journal of the American Society of Nephrology. 2016 ; Vol. 27, No. 5. pp. 1278-1287.
@article{31999d4e91514f22b03dfcbed3996d4c,
title = "Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN",
abstract = "Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aimof standardizing the kidney biopsy report ofGN.On the basis of etiology/ pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basementmembraneGN,monoclonal IgGN, andC3glomerulopathy.The pathogenesisbased classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.",
author = "Sethi, {Sanjeev M} and Mark Haas and Markowitz, {Glen S.} and D'Agati, {Vivette D.} and Rennke, {Helmut G.} and Jennette, {J. Charles} and Bajema, {Ingeborg M.} and Alpers, {Charles E.} and Anthony Chang and Cornell, {Lynn D.} and Cosio, {Fernando G} and Fogo, {Agnes B.} and Glassock, {Richard J.} and Sundaram Hariharan and Neeraja Kambham and Lager, {Donna J.} and Nelson Leung and Michael Mengel and Nath, {Karl A} and Roberts, {Ian S.} and Rovin, {Brad H.} and Seshan, {Surya V.} and Smith, {Richard J.H.} and Walker, {Patrick D.} and Winearls, {Christopher G.} and Appel, {Gerald B.} and Alexander, {Mariam P} and Cattran, {Daniel C.} and Casado, {Carmen Avila} and Cook, {H. Terence} and {De Vriese}, {An S.} and Jai Radhakrishnan and Racusen, {Lorraine C.} and Pierre Ronco and Fervenza, {Fernando Custodio}",
year = "2016",
month = "5",
day = "1",
doi = "10.1681/ASN.2015060612",
language = "English (US)",
volume = "27",
pages = "1278--1287",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "5",

}

TY - JOUR

T1 - Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN

AU - Sethi, Sanjeev M

AU - Haas, Mark

AU - Markowitz, Glen S.

AU - D'Agati, Vivette D.

AU - Rennke, Helmut G.

AU - Jennette, J. Charles

AU - Bajema, Ingeborg M.

AU - Alpers, Charles E.

AU - Chang, Anthony

AU - Cornell, Lynn D.

AU - Cosio, Fernando G

AU - Fogo, Agnes B.

AU - Glassock, Richard J.

AU - Hariharan, Sundaram

AU - Kambham, Neeraja

AU - Lager, Donna J.

AU - Leung, Nelson

AU - Mengel, Michael

AU - Nath, Karl A

AU - Roberts, Ian S.

AU - Rovin, Brad H.

AU - Seshan, Surya V.

AU - Smith, Richard J.H.

AU - Walker, Patrick D.

AU - Winearls, Christopher G.

AU - Appel, Gerald B.

AU - Alexander, Mariam P

AU - Cattran, Daniel C.

AU - Casado, Carmen Avila

AU - Cook, H. Terence

AU - De Vriese, An S.

AU - Radhakrishnan, Jai

AU - Racusen, Lorraine C.

AU - Ronco, Pierre

AU - Fervenza, Fernando Custodio

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aimof standardizing the kidney biopsy report ofGN.On the basis of etiology/ pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basementmembraneGN,monoclonal IgGN, andC3glomerulopathy.The pathogenesisbased classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

AB - Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aimof standardizing the kidney biopsy report ofGN.On the basis of etiology/ pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basementmembraneGN,monoclonal IgGN, andC3glomerulopathy.The pathogenesisbased classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

UR - http://www.scopus.com/inward/record.url?scp=84993670866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84993670866&partnerID=8YFLogxK

U2 - 10.1681/ASN.2015060612

DO - 10.1681/ASN.2015060612

M3 - Article

VL - 27

SP - 1278

EP - 1287

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 5

ER -