Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN

Sanjeev Sethi, Mark Haas, Glen S. Markowitz, Vivette D. D'Agati, Helmut G. Rennke, J. Charles Jennette, Ingeborg M. Bajema, Charles E. Alpers, Anthony Chang, Lynn D. Cornell, Fernando G. Cosio, Agnes B. Fogo, Richard J. Glassock, Sundaram Hariharan, Neeraja Kambham, Donna J. Lager, Nelson Leung, Michael Mengel, Karl A. Nath, Ian S. RobertsBrad H. Rovin, Surya V. Seshan, Richard J.H. Smith, Patrick D. Walker, Christopher G. Winearls, Gerald B. Appel, Mariam P. Alexander, Daniel C. Cattran, Carmen Avila Casado, H. Terence Cook, An S. De Vriese, Jai Radhakrishnan, Lorraine C. Racusen, Pierre Ronco, Fernando C. Fervenza

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aimof standardizing the kidney biopsy report ofGN.On the basis of etiology/ pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basementmembraneGN,monoclonal IgGN, andC3glomerulopathy.The pathogenesisbased classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

Original languageEnglish (US)
Pages (from-to)1278-1287
Number of pages10
JournalJournal of the American Society of Nephrology
Volume27
Issue number5
DOIs
StatePublished - May 2016

ASJC Scopus subject areas

  • Nephrology

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    Sethi, S., Haas, M., Markowitz, G. S., D'Agati, V. D., Rennke, H. G., Jennette, J. C., Bajema, I. M., Alpers, C. E., Chang, A., Cornell, L. D., Cosio, F. G., Fogo, A. B., Glassock, R. J., Hariharan, S., Kambham, N., Lager, D. J., Leung, N., Mengel, M., Nath, K. A., ... Fervenza, F. C. (2016). Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN. Journal of the American Society of Nephrology, 27(5), 1278-1287. https://doi.org/10.1681/ASN.2015060612