Mayo clinic cancer center experience of metastatic extramammary Paget disease 1998-2012

Leslie Padrnos, Nina Karlin, Thorvardur R. Halfdanarson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Extramammary Paget disease (EMPD) is a rare cutaneous malignancy. The most common presentation of EMPD is the vulva followed by perianal involvement. Most cases are localized to the dermis with treatment focused on surgery, topical treatment or radiotherapy. Recurrence is frequent despite therapies utilized. Metastatic extramammary Paget disease is uncommon and, as such, standard treatment guidelines do not exist. This study sought to evaluate the treatment regimens and outcomes of patients treated at a Mayo Clinic Center from 1998-2012. Cancer registry inquiry revealed 261 patients with report advanced Paget disease during these years. Ten cases of metastatic EPMD were identified with sufficient documentation for review. This review reveals support for utilizing localized radiation therapy for bulky disease sequentially with systemic chemotherapy consisting of carboplatin and paclitaxel or irinotecan. Further studies are necessary to define the optimal treatment regimen.

Original languageEnglish (US)
Article number6804
Pages (from-to)142-145
Number of pages4
JournalRare Tumors
Volume8
Issue number4
DOIs
StatePublished - Nov 17 2016

Keywords

  • Extramammary paget
  • Metastatic paget
  • Systemic therapy

ASJC Scopus subject areas

  • Histology
  • Oncology

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