TY - JOUR
T1 - Maximal exercise responses to acute and chronic beta-adrenergic blockade in healthy male subjects
AU - Jilka, Sarah M.
AU - Joyner, Michael J.
AU - Nittolo, Joyce M.
AU - Kalis, Joni K.
AU - Andrew Taylor, J.
AU - Lohman, Timothy G.
AU - Wilmore, Jack H.
PY - 1988/12
Y1 - 1988/12
N2 - JILKA, S. M., M. J. JOYNER, J. M. NITTOLO, J. K. KALIS, J. A. TAYLOR, T. G. LOHMAN, and J. H. WILMORE. Maximal exercise responses to acute and chronic beta-adrenergic blockade in healthy male subjects. Med. Sci. Sports Exerc., Vol. 20, No. 6, pp. 570-573, 1988. Conflicting data on the alterations in the maximal exercise response to beta blockade (BB) may be the result of differences in the length of time the subject has been on medication, i.e., hours vs days. The purpose of this study was to examine maximal exercise responses during acute and chronic administration of BB. Twenty-eight healthy males, 14 untrained (UT) and 14 involved in a personal training regimen (TR), performed maximal treadmill tests after 1 d and 9 d under three double-blind, randomized conditions: A placebo (PLAC), propranolol (PROP) 80 mg b.i.d., and atenolol (ATEN) 100 mg o.d. Maximal heart rate (HR), oxygen consumption (VO2), ventilation (VE), and treadmill time were significantly reduced by PROP and ATEN after an acute and chronic dose when compared to PLAC (P < 0.05) in both groups of subjects. Maximal HR was decreased more after 1 d of BB than after 9 d of BB with both PROP and ATEN in the UT subjects and with PROP only in the TR group. VO2max, VEmaxand treadmill time were also less attenuated after 9 d of BB; however, this trend did not reach statistical significance. The nonselective beta blocker, PROP, caused greater reductions in VO2maxcompared to the selective beta blocker, ATEN, in both groups of subjects. These data indicate that, other than a small change in maximal HR, there is no difference in the exercise response to acute and chronic BB in normal and highly conditioned individuals.
AB - JILKA, S. M., M. J. JOYNER, J. M. NITTOLO, J. K. KALIS, J. A. TAYLOR, T. G. LOHMAN, and J. H. WILMORE. Maximal exercise responses to acute and chronic beta-adrenergic blockade in healthy male subjects. Med. Sci. Sports Exerc., Vol. 20, No. 6, pp. 570-573, 1988. Conflicting data on the alterations in the maximal exercise response to beta blockade (BB) may be the result of differences in the length of time the subject has been on medication, i.e., hours vs days. The purpose of this study was to examine maximal exercise responses during acute and chronic administration of BB. Twenty-eight healthy males, 14 untrained (UT) and 14 involved in a personal training regimen (TR), performed maximal treadmill tests after 1 d and 9 d under three double-blind, randomized conditions: A placebo (PLAC), propranolol (PROP) 80 mg b.i.d., and atenolol (ATEN) 100 mg o.d. Maximal heart rate (HR), oxygen consumption (VO2), ventilation (VE), and treadmill time were significantly reduced by PROP and ATEN after an acute and chronic dose when compared to PLAC (P < 0.05) in both groups of subjects. Maximal HR was decreased more after 1 d of BB than after 9 d of BB with both PROP and ATEN in the UT subjects and with PROP only in the TR group. VO2max, VEmaxand treadmill time were also less attenuated after 9 d of BB; however, this trend did not reach statistical significance. The nonselective beta blocker, PROP, caused greater reductions in VO2maxcompared to the selective beta blocker, ATEN, in both groups of subjects. These data indicate that, other than a small change in maximal HR, there is no difference in the exercise response to acute and chronic BB in normal and highly conditioned individuals.
KW - Beta-adrenergic blockade
KW - Maximal exercise
KW - Trained vs untrained
KW - VE
KW - VO
UR - http://www.scopus.com/inward/record.url?scp=0024253762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024253762&partnerID=8YFLogxK
U2 - 10.1249/00005768-198812000-00009
DO - 10.1249/00005768-198812000-00009
M3 - Article
C2 - 2907080
AN - SCOPUS:0024253762
SN - 0195-9131
VL - 20
SP - 570
EP - 573
JO - Medicine and science in sports and exercise
JF - Medicine and science in sports and exercise
IS - 6
ER -