Maximal exercise responses to acute and chronic beta-adrenergic blockade in healthy male subjects

Sarah M. Jilka, Michael J. Joyner, Joyce M. Nittolo, Joni K. Kalis, J. Andrew Taylor, Timothy G. Lohman, Jack H. Wilmore

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

JILKA, S. M., M. J. JOYNER, J. M. NITTOLO, J. K. KALIS, J. A. TAYLOR, T. G. LOHMAN, and J. H. WILMORE. Maximal exercise responses to acute and chronic beta-adrenergic blockade in healthy male subjects. Med. Sci. Sports Exerc., Vol. 20, No. 6, pp. 570-573, 1988. Conflicting data on the alterations in the maximal exercise response to beta blockade (BB) may be the result of differences in the length of time the subject has been on medication, i.e., hours vs days. The purpose of this study was to examine maximal exercise responses during acute and chronic administration of BB. Twenty-eight healthy males, 14 untrained (UT) and 14 involved in a personal training regimen (TR), performed maximal treadmill tests after 1 d and 9 d under three double-blind, randomized conditions: A placebo (PLAC), propranolol (PROP) 80 mg b.i.d., and atenolol (ATEN) 100 mg o.d. Maximal heart rate (HR), oxygen consumption (VO2), ventilation (VE), and treadmill time were significantly reduced by PROP and ATEN after an acute and chronic dose when compared to PLAC (P < 0.05) in both groups of subjects. Maximal HR was decreased more after 1 d of BB than after 9 d of BB with both PROP and ATEN in the UT subjects and with PROP only in the TR group. VO2max, VEmaxand treadmill time were also less attenuated after 9 d of BB; however, this trend did not reach statistical significance. The nonselective beta blocker, PROP, caused greater reductions in VO2maxcompared to the selective beta blocker, ATEN, in both groups of subjects. These data indicate that, other than a small change in maximal HR, there is no difference in the exercise response to acute and chronic BB in normal and highly conditioned individuals.

Original languageEnglish (US)
Pages (from-to)570-573
Number of pages4
JournalMedicine and science in sports and exercise
Volume20
Issue number6
DOIs
StatePublished - Dec 1988

Keywords

  • Beta-adrenergic blockade
  • Maximal exercise
  • Trained vs untrained
  • VE
  • VO

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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