Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Jin Moo Lee, Kejie Yin, Idar Hsin, Shawei Chen, John D. Fryer, David M. Holtzman, Chung Y. Hsu, Jian Xu

Research output: Contribution to journalArticle

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Abstract

Spontaneous intracerebral hemorrhage (ICH) is one of the most recognized complications of cerebral amyloid angiopathy (CAA), but little is known about the molecular pathogenesis of this life-threatening complication. In this review, we present preliminary evidence which suggests that the extracellular-matrix-degrading protease, matrix metalloproteinase-9 (MMP-9), may play a role in the development of spontaneous ICH resulting from CAA. The amyloid-beta peptide (Aβ) induced the synthesis, cellular release, and activation of MMP-9 in murine cerebral endothelial cells (CECs), resulting in increased extracellular matrix (ECM) degradation. Furthermore, in a mouse model of CAA (APPsw transgenic mice), MMP-9 immunoreactivity was observed in amyloid-laden cerebral vessels in aged APPsw mice but not in young APPsw or aged wild-type mice. More extensive MMP-9 immunostaining was present in amyloid-laden vessels with evidence of microhemorrhage. These results suggest that increased vascular MMP-9 expression, stimulated by Aβ, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage (ICH) in patients with CAA.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournal of the Neurological Sciences
Volume229-230
DOIs
StatePublished - Mar 15 2005
Externally publishedYes

Fingerprint

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Hemorrhage
Cerebral Hemorrhage
Amyloid
Extracellular Matrix
Amyloid beta-Peptides
Transgenic Mice
Blood Vessels
Peptide Hydrolases
Endothelial Cells

Keywords

  • Alzheimer's disease
  • Amyloid-beta peptide
  • Cerebral amyloid angiopathy
  • Endothelial cells
  • Intracerebral hemorrhage
  • Matrix metalloproteinase-9, gelatinase B

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. / Lee, Jin Moo; Yin, Kejie; Hsin, Idar; Chen, Shawei; Fryer, John D.; Holtzman, David M.; Hsu, Chung Y.; Xu, Jian.

In: Journal of the Neurological Sciences, Vol. 229-230, 15.03.2005, p. 249-254.

Research output: Contribution to journalArticle

Lee, Jin Moo ; Yin, Kejie ; Hsin, Idar ; Chen, Shawei ; Fryer, John D. ; Holtzman, David M. ; Hsu, Chung Y. ; Xu, Jian. / Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. In: Journal of the Neurological Sciences. 2005 ; Vol. 229-230. pp. 249-254.
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