Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: A randomized controlled trial

Sara S. Oberhelman, Michael E. Meekins, Philip R. Fischer, Bernard R. Lee, Ravinder Jit Singh, Stephen S. Cha, Brian M. Gardner, John M. Pettifor, Ivana T Croghan, Tom D. Thacher

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Abstract

Objective: To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Patients and Methods: Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011. Results: In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87). Infant mean serum 25-hydroxyvitamin D concentration increased from 17±13 to 39±6 ng/mL in the single-dose group and from 16±12 to 39±12 ng/mL in the daily-dose group (P=.88). All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL. Conclusion: Either single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants.

Original languageEnglish (US)
Pages (from-to)1378-1387
Number of pages10
JournalMayo Clinic Proceedings
Volume88
Issue number12
DOIs
StatePublished - 2013

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Cholecalciferol
Vitamin D
Breast
Randomized Controlled Trials
Human Milk
Mothers
Serum
Milk
Urine

ASJC Scopus subject areas

  • Medicine(all)

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Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants : A randomized controlled trial. / Oberhelman, Sara S.; Meekins, Michael E.; Fischer, Philip R.; Lee, Bernard R.; Singh, Ravinder Jit; Cha, Stephen S.; Gardner, Brian M.; Pettifor, John M.; Croghan, Ivana T; Thacher, Tom D.

In: Mayo Clinic Proceedings, Vol. 88, No. 12, 2013, p. 1378-1387.

Research output: Contribution to journalArticle

Oberhelman, SS, Meekins, ME, Fischer, PR, Lee, BR, Singh, RJ, Cha, SS, Gardner, BM, Pettifor, JM, Croghan, IT & Thacher, TD 2013, 'Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: A randomized controlled trial', Mayo Clinic Proceedings, vol. 88, no. 12, pp. 1378-1387. https://doi.org/10.1016/j.mayocp.2013.09.012
Oberhelman, Sara S. ; Meekins, Michael E. ; Fischer, Philip R. ; Lee, Bernard R. ; Singh, Ravinder Jit ; Cha, Stephen S. ; Gardner, Brian M. ; Pettifor, John M. ; Croghan, Ivana T ; Thacher, Tom D. / Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants : A randomized controlled trial. In: Mayo Clinic Proceedings. 2013 ; Vol. 88, No. 12. pp. 1378-1387.
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AU - Meekins, Michael E.

AU - Fischer, Philip R.

AU - Lee, Bernard R.

AU - Singh, Ravinder Jit

AU - Cha, Stephen S.

AU - Gardner, Brian M.

AU - Pettifor, John M.

AU - Croghan, Ivana T

AU - Thacher, Tom D.

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N2 - Objective: To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Patients and Methods: Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011. Results: In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87). Infant mean serum 25-hydroxyvitamin D concentration increased from 17±13 to 39±6 ng/mL in the single-dose group and from 16±12 to 39±12 ng/mL in the daily-dose group (P=.88). All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL. Conclusion: Either single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants.

AB - Objective: To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Patients and Methods: Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011. Results: In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87). Infant mean serum 25-hydroxyvitamin D concentration increased from 17±13 to 39±6 ng/mL in the single-dose group and from 16±12 to 39±12 ng/mL in the daily-dose group (P=.88). All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL. Conclusion: Either single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants.

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