Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

Eun Kyung Kim; Myoung Hwa Lee; Hong Kim; Young Je Sim; Mal Soon Shin; Sam Jun Lee; Hye Young Yang; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Hee Hyuk Lee; Chang Ju Kim

doi:10.1016/j.braindev.2004.11.008

Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

Eun Kyung Kim, Myoung Hwa Lee, Hong Kim, Young Je Sim, Mal Soon Shin, Sam Jun Lee, Hye Young Yang, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Hee Hyuk Lee, Chang Ju Kim

Neurosurgery

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10 Scopus citations

Abstract

Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.

Original language	English (US)
Pages (from-to)	472-476
Number of pages	5
Journal	Brain and Development
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.braindev.2004.11.008
State	Published - Oct 2005

Keywords

5-Hydroxytryptamine
Dorsal raphe
Maternal ethanol intake
Tryptophan hydroxylase

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Clinical Neurology

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10.1016/j.braindev.2004.11.008

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Kim, E. K., Lee, M. H., Kim, H., Sim, Y. J., Shin, M. S., Lee, S. J., Yang, H. Y., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, H. H., & Kim, C. J. (2005). Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring. Brain and Development, 27(7), 472-476. https://doi.org/10.1016/j.braindev.2004.11.008

Kim, EK, Lee, MH, Kim, H, Sim, YJ, Shin, MS, Lee, SJ, Yang, HY, Chang, HK, Lee, TH, Jang, MH, Shin, MC, Lee, HH & Kim, CJ 2005, 'Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring', Brain and Development, vol. 27, no. 7, pp. 472-476. https://doi.org/10.1016/j.braindev.2004.11.008

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title = "Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring",

abstract = "Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.",

keywords = "5-Hydroxytryptamine, Dorsal raphe, Maternal ethanol intake, Tryptophan hydroxylase",

author = "Kim, {Eun Kyung} and Lee, {Myoung Hwa} and Hong Kim and Sim, {Young Je} and Shin, {Mal Soon} and Lee, {Sam Jun} and Yang, {Hye Young} and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Hee Hyuk} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by a Research Foundation Grant (KRF-2003-037-G00045).",

year = "2005",

month = oct,

doi = "10.1016/j.braindev.2004.11.008",

language = "English (US)",

volume = "27",

pages = "472--476",

journal = "Brain and Development",

issn = "0387-7604",

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T1 - Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

AU - Kim, Eun Kyung

AU - Lee, Myoung Hwa

AU - Kim, Hong

AU - Sim, Young Je

AU - Shin, Mal Soon

AU - Lee, Sam Jun

AU - Yang, Hye Young

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Hee Hyuk

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by a Research Foundation Grant (KRF-2003-037-G00045).

PY - 2005/10

Y1 - 2005/10

N2 - Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.

AB - Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.

KW - 5-Hydroxytryptamine

KW - Dorsal raphe

KW - Maternal ethanol intake

KW - Tryptophan hydroxylase

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Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

Abstract

Keywords

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