Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring

Eun Kyung Kim, Myoung Hwa Lee, Hong Kim, Young Je Sim, Mal Soon Shin, Sam Jun Lee, Hye Young Yang, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Hee Hyuk Lee, Chang Ju Kim

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9 Scopus citations

Abstract

Maternal ethanol consumption during pregnancy has a detrimental effect on the central nervous system (CNS) development of fetus. 5-Hydroxytryptamine (5-HT) is an important neurotransmitter and/or neuromodulator in the mammalian CNS. Tryptophan hydroxylase (TPH) is the rate limiting enzyme of 5-HT synthesis. Ethanol is known to induce neuropsychiatric disorders by alteration of the central serotonergic system. In the present study, the effects of maternal ethanol intake on the 5-HT synthesis and the TPH expression in the dorsal raphe of rat offspring were investigated. The present results show that the synthesis of 5-HT and the expression of TPH in the dorsal raphe of rat offspring were suppressed by maternal ethanol intake and that the suppressive effect of alcohol was more potent in the 5 weeks old rat pups compared to the 3 weeks old rat pups. Based on the present study, it can be suggested that the pathogenesis of ethanol-induced neuropsychological disorders involves ethanol-induced suppression on the 5-HT synthesis and the TPH expression in the dorsal raphe of offspring.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalBrain and Development
Volume27
Issue number7
DOIs
StatePublished - Oct 1 2005

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Keywords

  • 5-Hydroxytryptamine
  • Dorsal raphe
  • Maternal ethanol intake
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kim, E. K., Lee, M. H., Kim, H., Sim, Y. J., Shin, M. S., Lee, S. J., Yang, H. Y., Chang, H. K., Lee, T. H., Jang, M. H., Shin, M. C., Lee, H. H., & Kim, C. J. (2005). Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring. Brain and Development, 27(7), 472-476. https://doi.org/10.1016/j.braindev.2004.11.008