Maternal and fetal outcome after colectomy for fulminant ulcerative colitis during pregnancy: Case series and literature review

Eric Dozois, Bruce G. Wolff, William J. Tremaine, William J. Watson, Ernesto R. Drelichman, P. W G Carne, Julie L. Bakken

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

PURPOSE: Previous studies have reported high morbidity and mortality in mothers and their offspring after colectomy for ulcerative colitis during pregnancy. This study was designed to assess the maternal and fetal outcomes of pregnant females undergoing colectomy for ulcerative colitis in the current era. METHODS: A retrospective analysis was performed at our institution of all pregnant females undergoing operation for ulcerative colitis between 1980 and 2004. To compare this data to that of past literature, a MEDLINE search from 1951 to 2004 reviewed all cases reported on this topic. RESULTS: Between 1980 and 2004, five females underwent an operation at our institution for fulminant ulcerative colitis while pregnant. All five patients underwent subtotal colectomy with Brooke ileostomy. Postoperative maternal morbidity included a superficial wound infection and a small asymptomatic intra-abdominal abscess. All females had successful pregnancies, and no maternal or fetal deaths occurred. Two patients went on to have an ileal pouch-anal anastomosis, one had a completion proctectomy and end ileostomy, oneis scheduled for an ileal pouch-anal anastomosis, andone patient is lost to follow-up. The literature review revealed 37 cases. The overall fetal and maternal mortality was 49 and 22 percent respectively. Postoperative maternal morbidity was reported in 24 percent. CONCLUSIONS: In contrast to historic data, the maternal and fetal mortality from our series was zero and maternal morbidity was low. Subtotal colectomy and Brooke ileostomy for ulcerative colitis during pregnancy is safe. A multidisciplinary team that includes a gastroenterologist, high-risk obstetrician, and experienced surgeon is necessary for an optimal outcome.

Original languageEnglish (US)
Pages (from-to)64-73
Number of pages10
JournalDiseases of the Colon and Rectum
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Colectomy
Ulcerative Colitis
Ileostomy
Mothers
Pregnancy
Morbidity
Fetal Mortality
Colonic Pouches
Maternal Mortality
Abdominal Abscess
Maternal Death
Fetal Death
Lost to Follow-Up
Wound Infection
MEDLINE
Mortality

Keywords

  • Colectomy
  • Fulminant ulcerative colitis
  • Pregnancy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Maternal and fetal outcome after colectomy for fulminant ulcerative colitis during pregnancy : Case series and literature review. / Dozois, Eric; Wolff, Bruce G.; Tremaine, William J.; Watson, William J.; Drelichman, Ernesto R.; Carne, P. W G; Bakken, Julie L.

In: Diseases of the Colon and Rectum, Vol. 49, No. 1, 01.01.2006, p. 64-73.

Research output: Contribution to journalArticle

Dozois, Eric ; Wolff, Bruce G. ; Tremaine, William J. ; Watson, William J. ; Drelichman, Ernesto R. ; Carne, P. W G ; Bakken, Julie L. / Maternal and fetal outcome after colectomy for fulminant ulcerative colitis during pregnancy : Case series and literature review. In: Diseases of the Colon and Rectum. 2006 ; Vol. 49, No. 1. pp. 64-73.
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