Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Mi Hyeon Jang; Myoung Hwa Lee; Hong Kim; Sam Jun Lee; Young Je Sim; Chang Ju Kim; Se Keun Park; Jeongseon Kim; Ee Hwa Kim

doi:10.1254/jphs.SC0050060

Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Mi Hyeon Jang, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Chang Ju Kim, Se Keun Park, Jeongseon Kim, Ee Hwa Kim

Neurosurgery

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4 Scopus citations

Abstract

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

Original language	English (US)
Pages (from-to)	459-462
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	98
Issue number	4
DOIs	https://doi.org/10.1254/jphs.SC0050060
State	Published - 2005

Keywords

Hippocampus
Maternal alcohol
Nitric oxide synthase

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.SC0050060

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Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats. / Jang, Mi Hyeon; Lee, Myoung Hwa; Kim, Hong; Lee, Sam Jun; Sim, Young Je; Kim, Chang Ju; Park, Se Keun; Kim, Jeongseon; Kim, Ee Hwa.

In: Journal of Pharmacological Sciences, Vol. 98, No. 4, 2005, p. 459-462.

Research output: Contribution to journal › Article › peer-review

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abstract = "Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.",

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AU - Jang, Mi Hyeon

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AU - Sim, Young Je

AU - Kim, Chang Ju

AU - Park, Se Keun

AU - Kim, Jeongseon

AU - Kim, Ee Hwa

PY - 2005

Y1 - 2005

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KW - Maternal alcohol

KW - Nitric oxide synthase

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Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Abstract

Keywords

ASJC Scopus subject areas

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