Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Mi Hyeon Jang, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Chang Ju Kim, Se Keun Park, Jeongseon Kim, Ee Hwa Kim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

Original languageEnglish (US)
Pages (from-to)459-462
Number of pages4
JournalJournal of Pharmacological Sciences
Volume98
Issue number4
DOIs
StatePublished - 2005

Keywords

  • Hippocampus
  • Maternal alcohol
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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