Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Mi Hyeon Jang; Myoung Hwa Lee; Hong Kim; Sam Jun Lee; Young Je Sim; Chang Ju Kim; Se Keun Park; Jeongseon Kim; Ee Hwa Kim

doi:10.1254/jphs.SC0050060

Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Mi Hyeon Jang, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Chang Ju Kim, Se Keun Park, Jeongseon Kim, Ee Hwa Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

Original language	English (US)
Pages (from-to)	459-462
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	98
Issue number	4
DOIs	https://doi.org/10.1254/jphs.SC0050060
State	Published - 2005

Keywords

Hippocampus
Maternal alcohol
Nitric oxide synthase

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Access to Document

10.1254/jphs.SC0050060

Cite this

@article{6ef1b1ad8ffc4747abd854c61b8e4dac,

title = "Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats",

abstract = "Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.",

keywords = "Hippocampus, Maternal alcohol, Nitric oxide synthase",

author = "Jang, {Mi Hyeon} and Lee, {Myoung Hwa} and Hong Kim and Lee, {Sam Jun} and Sim, {Young Je} and Kim, {Chang Ju} and Park, {Se Keun} and Jeongseon Kim and Kim, {Ee Hwa}",

year = "2005",

doi = "10.1254/jphs.SC0050060",

language = "English (US)",

volume = "98",

pages = "459--462",

journal = "Journal of Pharmacological Sciences",

issn = "1347-8613",

publisher = "Japanese Pharmacological Society",

number = "4",

}

TY - JOUR

T1 - Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

AU - Jang, Mi Hyeon

AU - Lee, Myoung Hwa

AU - Kim, Hong

AU - Lee, Sam Jun

AU - Sim, Young Je

AU - Kim, Chang Ju

AU - Park, Se Keun

AU - Kim, Jeongseon

AU - Kim, Ee Hwa

PY - 2005

Y1 - 2005

N2 - Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

AB - Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

KW - Hippocampus

KW - Maternal alcohol

KW - Nitric oxide synthase

UR - http://www.scopus.com/inward/record.url?scp=24744452030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24744452030&partnerID=8YFLogxK

U2 - 10.1254/jphs.SC0050060

DO - 10.1254/jphs.SC0050060

M3 - Article

C2 - 16082173

AN - SCOPUS:24744452030

VL - 98

SP - 459

EP - 462

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 4

ER -

Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this