MASTERMIND: Bringing microbial diagnostics to the clinic

Robin Patel, Ephraim L. Tsalik, Elizabeth Petzold, Vance G. Fowler, Jeffrey D. Klausner, Scott Evans

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs. MASTERMIND uses a single subject's sample(s) to evaluate multiple diagnostic tests at the same time, providing efficiencies of specimen collection and characterization. MASTERMIND also offers central trial organization, standardization of methods and definitions, and common comparators.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalClinical Infectious Diseases
Volume64
Issue number3
DOIs
StatePublished - 2017

Keywords

  • Communicable diseases
  • Molecular diagnostic techniques
  • Reference standards

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Patel, R., Tsalik, E. L., Petzold, E., Fowler, V. G., Klausner, J. D., & Evans, S. (2017). MASTERMIND: Bringing microbial diagnostics to the clinic. Clinical Infectious Diseases, 64(3), 355-360. https://doi.org/10.1093/cid/ciw788