TY - JOUR
T1 - Mast cells in tumor growth
T2 - Angiogenesis, tissue remodelling and immune-modulation
AU - Maltby, Steven
AU - Khazaie, Khashayarsha
AU - McNagny, Kelly M.
N1 - Funding Information:
The authors would like to thank Vicki MacDonald for assistance in preparing this manuscript and producing the figures. SM holds a Canadian Institutes of Health Research (CIHR) and the Heart and Stroke Foundation of Canada Transfusion Science Fellowship from the Centre for Blood Research (CBR) at the University of British Columbia. KK is a recipient of an American Society for Cancer Research Award. KMM is a Michael Smith Foundation for Health Research Scholar (Senior) and CBR Member. This work was funded by grants from NIH (R01-CA104547), the Canadian Institutes of Health Research (MOP-84545) and the Allergen Network Centre of Excellence (Project 3.13).
PY - 2009/8
Y1 - 2009/8
N2 - There is a growing acceptance that tumor-infiltrating myeloid cells play an active role in tumor growth and mast cells are one of the earliest cell types to infiltrate developing tumors. Mast cells accumulate at the boundary between healthy tissues and malignancies and are often found in close association with blood vessels within the tumor microenvironment. They express many pro-angiogenic compounds, and may play an early role in angiogenesis within developing tumors. Mast cells also remodel extracellular matrix during wound healing, and this function is subverted in tumor growth, promoting tumor spread and metastasis. In addition, mast cells modulate immune responses by dampening immune rejection or directing immune cell recruitment, depending on local stimuli. In this review, we focus on key roles for mast cells in angiogenesis, tissue remodelling and immune modulation and highlight recent findings on the integral role that mast cells play in tumor growth. New findings suggest that mast cells may serve as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may lead to tumor regression.
AB - There is a growing acceptance that tumor-infiltrating myeloid cells play an active role in tumor growth and mast cells are one of the earliest cell types to infiltrate developing tumors. Mast cells accumulate at the boundary between healthy tissues and malignancies and are often found in close association with blood vessels within the tumor microenvironment. They express many pro-angiogenic compounds, and may play an early role in angiogenesis within developing tumors. Mast cells also remodel extracellular matrix during wound healing, and this function is subverted in tumor growth, promoting tumor spread and metastasis. In addition, mast cells modulate immune responses by dampening immune rejection or directing immune cell recruitment, depending on local stimuli. In this review, we focus on key roles for mast cells in angiogenesis, tissue remodelling and immune modulation and highlight recent findings on the integral role that mast cells play in tumor growth. New findings suggest that mast cells may serve as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may lead to tumor regression.
KW - Angiogenesis
KW - Cancer
KW - Immune-modulation
KW - Immunity
KW - Mast cell
KW - Remodelling
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U2 - 10.1016/j.bbcan.2009.02.001
DO - 10.1016/j.bbcan.2009.02.001
M3 - Review article
C2 - 19233249
AN - SCOPUS:69049117556
SN - 0304-419X
VL - 1796
SP - 19
EP - 26
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 1
ER -