Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation

Steven Maltby, Khashayarsha Khazaie, Kelly M. McNagny

Research output: Contribution to journalReview article

202 Scopus citations

Abstract

There is a growing acceptance that tumor-infiltrating myeloid cells play an active role in tumor growth and mast cells are one of the earliest cell types to infiltrate developing tumors. Mast cells accumulate at the boundary between healthy tissues and malignancies and are often found in close association with blood vessels within the tumor microenvironment. They express many pro-angiogenic compounds, and may play an early role in angiogenesis within developing tumors. Mast cells also remodel extracellular matrix during wound healing, and this function is subverted in tumor growth, promoting tumor spread and metastasis. In addition, mast cells modulate immune responses by dampening immune rejection or directing immune cell recruitment, depending on local stimuli. In this review, we focus on key roles for mast cells in angiogenesis, tissue remodelling and immune modulation and highlight recent findings on the integral role that mast cells play in tumor growth. New findings suggest that mast cells may serve as a novel therapeutic target for cancer treatment and that inhibiting mast cell function may lead to tumor regression.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1796
Issue number1
DOIs
StatePublished - Aug 2009

Keywords

  • Angiogenesis
  • Cancer
  • Immune-modulation
  • Immunity
  • Mast cell
  • Remodelling

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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