Mass spectrometry methods for metabolic and health assessment

D. Matern, M. J. Magera

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Beginning in the mid 1960s, mass spectrometry was introduced in a few academic laboratories for the analysis of organic acids by gas chromatography-mass spectrometry. Since then, multiple-stage mass spectrometers have become available and many new applications have been developed. Major advantages of these new techniques include their ability to rapidly determine many different compounds in complex biological matrices with high sensitivity and in sample volumes of usually < 100 μL. A high sample throughput is further realized because extensive sample preparations are often not necessary. However, because the technical know-how is not yet widely available and significant experience is required for correct interpretation of results, these methods are being implemented slowly in routine clinical laboratories as opposed to research laboratories. Several of these new applications are considered with regard to clinical medicine.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume131
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Mass Spectrometry
mass spectrometry
Clinical Medicine
Health
Gas Chromatography-Mass Spectrometry
spectrometers
sampling
Acids
organic acids and salts
medicine
methodology
Research
gas chromatography-mass spectrometry

Keywords

  • Inborn errors of metabolism
  • Mass spectrometry
  • Tandem mass spectrometry
  • Vitamin deficiencies

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Mass spectrometry methods for metabolic and health assessment. / Matern, D.; Magera, M. J.

In: Journal of Nutrition, Vol. 131, No. 5, 2001.

Research output: Contribution to journalArticle

Matern, D. ; Magera, M. J. / Mass spectrometry methods for metabolic and health assessment. In: Journal of Nutrition. 2001 ; Vol. 131, No. 5.
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