Mass-like extramedullary hematopoiesis

Imaging features

Andrew W. Ginzel, Mark J. Kransdorf, Jeffrey J. Peterson, Hillary W. Garner, Mark D. Murphey

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: To report the imaging appearances of mass-like extramedullary hematopoiesis (EMH), to identify those features that are sufficiently characteristic to allow a confident diagnosis, and to recognize the clinical conditions associated with EMH and the relative incidence of mass-like disease. Materials and methods: We retrospectively identified 44 patients with EMH; 12 of which (27%) had focal mass-like lesions and formed the study group. The study group consisted of 6 male and 6 female subjects with a mean age of 58 years (range 13-80 years). All 12 patients underwent CT imaging and 3 of the 12 patients had undergone additional MR imaging. The imaging characteristics of the extramedullary hematopoiesis lesions in the study group were analyzed and recorded. The patient's clinical presentation, including any condition associated with extramedullary hematopoiesis, was also recorded. Results: Ten of the 12 (83%) patients had one or more masses located along the axial skeleton. Of the 10 patients with axial masses, 9 (90%) had multiple masses and 7 (70%) demonstrated internal fat. Eight patients (80%) had paraspinal masses and 4 patients (40%) had presacral masses. Seven patients (70%) had splenomegaly. Eleven of the 12 patients had a clinical history available for review. A predisposing condition for extramedullary hematopoiesis was present in 10 patients and included various anemias (5 cases; 45%), myelofibrosis/ myelodysplastic syndrome (4 cases; 36%), and marrow proliferative disorder (1 case; 9%). One patient had no known predisposing condition. Conclusion: Mass-like extramedullary hematopoiesis most commonly presents as multiple, fat-containing lesions localized to the axial skeleton. When these imaging features are identified, extramedullary hematopoiesis should be strongly considered, particularly when occurring in the setting of a predisposing medical condition.

Original languageEnglish (US)
Pages (from-to)911-916
Number of pages6
JournalSkeletal Radiology
Volume41
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Extramedullary Hematopoiesis
Skeleton
Fats
Primary Myelofibrosis
Myelodysplastic Syndromes
Splenomegaly
Anemia

Keywords

  • CT imaging
  • Extramedullary hematopoiesis
  • MR imaging
  • Soft tissue mass

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ginzel, A. W., Kransdorf, M. J., Peterson, J. J., Garner, H. W., & Murphey, M. D. (2012). Mass-like extramedullary hematopoiesis: Imaging features. Skeletal Radiology, 41(8), 911-916. https://doi.org/10.1007/s00256-011-1323-z

Mass-like extramedullary hematopoiesis : Imaging features. / Ginzel, Andrew W.; Kransdorf, Mark J.; Peterson, Jeffrey J.; Garner, Hillary W.; Murphey, Mark D.

In: Skeletal Radiology, Vol. 41, No. 8, 08.2012, p. 911-916.

Research output: Contribution to journalArticle

Ginzel, AW, Kransdorf, MJ, Peterson, JJ, Garner, HW & Murphey, MD 2012, 'Mass-like extramedullary hematopoiesis: Imaging features', Skeletal Radiology, vol. 41, no. 8, pp. 911-916. https://doi.org/10.1007/s00256-011-1323-z
Ginzel AW, Kransdorf MJ, Peterson JJ, Garner HW, Murphey MD. Mass-like extramedullary hematopoiesis: Imaging features. Skeletal Radiology. 2012 Aug;41(8):911-916. https://doi.org/10.1007/s00256-011-1323-z
Ginzel, Andrew W. ; Kransdorf, Mark J. ; Peterson, Jeffrey J. ; Garner, Hillary W. ; Murphey, Mark D. / Mass-like extramedullary hematopoiesis : Imaging features. In: Skeletal Radiology. 2012 ; Vol. 41, No. 8. pp. 911-916.
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