Abstract
We sought to dissect the tumour microenvironment in a small cohort (N = 10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45+ and CD3+ compartments. Double positive T cells and PD-1 positive CD4 T cells were expanded and naïve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic-driven selection as a driver of disease pathogenesis in POEMS.
Original language | English (US) |
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Pages (from-to) | 79-83 |
Number of pages | 5 |
Journal | British journal of haematology |
Volume | 190 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 2020 |
Keywords
- immunohaematology
- immunophenotyping
- myeloma
- tumour immunology
ASJC Scopus subject areas
- Hematology