Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome

Taxiarchis V. Kourelis, Dragan Jevremovic, Erik Jessen, Surendra Dasari, Jose C. Villasboas, Angela Dispenzieri, Shaji Kumar

Research output: Contribution to journalArticle

Abstract

We sought to dissect the tumour microenvironment in a small cohort (N = 10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45+ and CD3+ compartments. Double positive T cells and PD-1 positive CD4 T cells were expanded and naïve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic-driven selection as a driver of disease pathogenesis in POEMS.

Original languageEnglish (US)
JournalBritish journal of haematology
DOIs
StateAccepted/In press - Jan 1 2020

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Keywords

  • immunohaematology
  • immunophenotyping
  • myeloma
  • tumour immunology

ASJC Scopus subject areas

  • Hematology

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