TY - JOUR
T1 - MARS
T2 - Should I Use It?
AU - Cheungpasitporn, Wisit
AU - Thongprayoon, Charat
AU - Zoghby, Ziad M.
AU - Kashani, Kianoush
N1 - Publisher Copyright:
© 2021 National Kidney Foundation, Inc.
PY - 2021/1
Y1 - 2021/1
N2 - Severe liver failure, including acute liver failure and acute-on-chronic liver failure, is associated with high mortality, and many patients die despite aggressive medical therapy. While liver transplantation is a viable treatment option for liver failure patients, a large proportion of these patients die given the shortage in the liver donation and the severity of illness, leading to death while waiting for a liver transplant. Extracorporeal liver support devices, including molecular adsorbent recirculating system (MARS), have been developed as bridge to transplantation (bridge for patients who are decompensating while waiting for liver transplantation) and bridge to recovery (for whom recovery is deemed reasonable). In addition to its uses in acute liver failure and acute-on-chronic liver failure, the MARS system has also been applied in various clinical settings, such as drug overdosing and poisoning and intractable cholestatic pruritus refractory to pharmacological treatment. This review aims to discuss the controversies, potential benefits, practicalities, and disadvantages of using MARS in clinical practice.
AB - Severe liver failure, including acute liver failure and acute-on-chronic liver failure, is associated with high mortality, and many patients die despite aggressive medical therapy. While liver transplantation is a viable treatment option for liver failure patients, a large proportion of these patients die given the shortage in the liver donation and the severity of illness, leading to death while waiting for a liver transplant. Extracorporeal liver support devices, including molecular adsorbent recirculating system (MARS), have been developed as bridge to transplantation (bridge for patients who are decompensating while waiting for liver transplantation) and bridge to recovery (for whom recovery is deemed reasonable). In addition to its uses in acute liver failure and acute-on-chronic liver failure, the MARS system has also been applied in various clinical settings, such as drug overdosing and poisoning and intractable cholestatic pruritus refractory to pharmacological treatment. This review aims to discuss the controversies, potential benefits, practicalities, and disadvantages of using MARS in clinical practice.
KW - Acute liver failure
KW - Albumin dialysis
KW - Artificial liver support
KW - Liver failure
KW - MARS
KW - Molecular adsorbent recirculating system
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U2 - 10.1053/j.ackd.2021.02.004
DO - 10.1053/j.ackd.2021.02.004
M3 - Review article
C2 - 34389137
AN - SCOPUS:85112295201
SN - 1548-5595
VL - 28
SP - 47
EP - 58
JO - Advances in Chronic Kidney Disease
JF - Advances in Chronic Kidney Disease
IS - 1
ER -