Markers used for visualization and quantification of blood and lymphatic vessels

Mohamed Salama, David A. Eberhard, Steven J. Potts

Research output: Contribution to journalArticlepeer-review

Abstract

In order to study angiogenesis and vascular networks in histology samples, an appropriate stain for endothelial cell surfaces is required. This chapter reviews the various possible antibodies used to identify blood and lymph vessel endothelium, and other vascular markers in both immune histochemical and immunofluorescent studies. Two categories of human endothelial cell-specific antibodies are commonly used: the pan-endothelial cell markers and antibodies that bind selectively to activated or proliferating endothelium. The chapter concludes with a review and discussion of potential clinical uses of angiogenesis quantification.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalMethods in Pharmacology and Toxicology
Volume20
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Angiogenesis
  • CD31
  • CD34
  • Digital pathology
  • Microvessel density
  • Tissue image analysis on intact
  • Vascular

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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