Markers used for visualization and quantification of blood and lymphatic vessels

Mohamed Salama, David A. Eberhard, Steven J. Potts

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In order to study angiogenesis and vascular networks in histology samples, an appropriate stain for endothelial cell surfaces is required. This chapter reviews the various possible antibodies used to identify blood and lymph vessel endothelium, and other vascular markers in both immunohistochemical and immunofluorescent studies. Two categories of human endothelial cell-specific antibodies are commonly used: the pan-endothelial cell markers and antibodies that bind selectively to activated or proliferating endothelium. The chapter concludes with a review and discussion of potential clinical uses of angiogenesis quantification.

Original languageEnglish (US)
Title of host publicationMolecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development
PublisherSpringer New York
Pages79-85
Number of pages7
ISBN (Electronic)9781493926817
ISBN (Print)9781493926800
DOIs
StatePublished - Jun 15 2015
Externally publishedYes

Keywords

  • Angiogenesis
  • CD31
  • CD34
  • Digital pathology
  • Microvessel density
  • Tissue image analysis
  • Vascular

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Salama, M., Eberhard, D. A., & Potts, S. J. (2015). Markers used for visualization and quantification of blood and lymphatic vessels. In Molecular Histopathology and Tissue Biomarkers in Drug and Diagnostic Development (pp. 79-85). Springer New York. https://doi.org/10.1007/7653_2014_32