Markedly Diminished Epidermal Keratinocyte Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Sézary Syndrome

Brian J. Nickoloff, Christopher E.M. Griffiths, Ole Baadsgaard, John J. Voorhees, Curtis A. Hanson, Kevin D. Cooper

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

In mycosis fungoides the malignant T cells express lymphocyte function-associated antigen-1, which allows them to bind to epidermal keratinocytes expressing the gamma interferon-inducible intercellular adhesion molecule-1. In this report, a patient with leukemic-stage mycosis fungoides (Sézary syndrome) had widespread erythematous dermal infiltrates containing malignant T cells, but without any epidermotropism. We discovered that the T cells expressed normal amounts of functional lymphocyte function-associated antigen-1, but the keratinocytes did not express significant levels of intercellular adhesion molecule-1, which was probably due to the inability of the malignant T cells to produce gamma interferon. These results support the concept that the inability of malignant T cells to enter the epidermis may contribute to emergence of more clinically aggressive T- cell clones that are no longer confined to the skin, but infiltrate the blood, lymph nodes, and viscera, as is seen in Sézary syndrome.

Original languageEnglish (US)
Pages (from-to)2217-2221
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume261
Issue number15
DOIs
StatePublished - Apr 21 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Markedly Diminished Epidermal Keratinocyte Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Sézary Syndrome'. Together they form a unique fingerprint.

  • Cite this