Abstract
Objective: To assess marked central canal T2-hyperintensity in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) myelitis compared to myelitis patients with aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and multiple sclerosis (MS). Material/methods: Two blinded raters evaluated spinal cord magnetic resonance imaging (MRIs) of myelitis patients with MOGAD (n = 63), AQP4 + NMOSD (n = 37), and MS (n = 26), assessing for marked central canal T2-hyperintensity and its evolution. If there were conflicting results, a third neurologist assessed the MRI. Results: Marked central canal T2-hyperintensity was more frequent in patients with MOGAD (18/63[29%]) than MS (1/26[4%]; p = 0.01) myelitis but did not differ from AQP4 + NMOSD (13/37[35%]; p = 0.49). Marked central canal T2-hyperintensity had completely resolved on follow-up axial MRI for most MOGAD (12/14[86%]) and AQP4 + NMOSD (10/10[100%]; p = 0.49) patients. Conclusions: Marked central canal T2-hyperintensity is a common transient radiologic accompaniment of MOGAD and AQP4 + NMOSD myelitis, but not MS myelitis.
Original language | English (US) |
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Article number | 120687 |
Journal | Journal of the neurological sciences |
Volume | 450 |
DOIs | |
State | Published - Jul 15 2023 |
Keywords
- Bright spotty
- Central canal
- MOG
- Multiple sclerosis
- Neuromyelitis optica spectrum disorder
- myelin oligodendrocyte glycoprotein
- myelin oligodendrocyte glycoprotein antibody-associated disease
ASJC Scopus subject areas
- Neurology
- Clinical Neurology