Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy

Gregory A. Poland, Kathryn R. Love

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A 38-year-old man presented with a generalized pruritic maculopapular rash, fever, myalgias, and edema of the face and neck. Laboratory examination revealed eosinophilia, atypical lymphocytosis, and abnormal liver function results. The clinical course was characterized by rapid resolution after initiation of steroid therapy and withdrawal of sulfasalazine, which had been started three weeks earlier for abdominal cramping and diarrhea. This clinical picture suggests a drug-induced hypersensitivity reaction to a drug commonly used for inflammatory bowel disease, sulfasalazine.

Original languageEnglish (US)
Pages (from-to)707-708
Number of pages2
JournalThe American Journal of Medicine
Volume81
Issue number4
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Medicine(all)

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