Marital status is an independent prognostic factor for tracheal cancer patients

An analysis of the SEER database

Mu Li, Chen Yang Dai, Yu Ning Wang, Tao Chen, Long Wang, Ping Yang, Dong Xie, Rui Mao, Chang Chen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.

Original languageEnglish (US)
Pages (from-to)77152-77162
Number of pages11
JournalOncotarget
Volume7
Issue number47
DOIs
StatePublished - 2016

Fingerprint

Marital Status
Epidemiology
Databases
Survival
Neoplasms
Confidence Intervals
Social Support
Multivariate Analysis
Regression Analysis

Keywords

  • Marital status
  • SEER
  • Socio-economics
  • Survival analysis
  • Tracheal cancer

ASJC Scopus subject areas

  • Oncology

Cite this

Marital status is an independent prognostic factor for tracheal cancer patients : An analysis of the SEER database. / Li, Mu; Dai, Chen Yang; Wang, Yu Ning; Chen, Tao; Wang, Long; Yang, Ping; Xie, Dong; Mao, Rui; Chen, Chang.

In: Oncotarget, Vol. 7, No. 47, 2016, p. 77152-77162.

Research output: Contribution to journalArticle

Li, Mu ; Dai, Chen Yang ; Wang, Yu Ning ; Chen, Tao ; Wang, Long ; Yang, Ping ; Xie, Dong ; Mao, Rui ; Chen, Chang. / Marital status is an independent prognostic factor for tracheal cancer patients : An analysis of the SEER database. In: Oncotarget. 2016 ; Vol. 7, No. 47. pp. 77152-77162.
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title = "Marital status is an independent prognostic factor for tracheal cancer patients: An analysis of the SEER database",
abstract = "Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67{\%}), married patients (57.33{\%}) had better 5-year OS (25.64{\%} vs. 35.89{\%}, p = 0.009) and 5-year TCSS (44.58{\%} vs. 58.75{\%}, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95{\%} confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95{\%} CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95{\%} CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.",
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T1 - Marital status is an independent prognostic factor for tracheal cancer patients

T2 - An analysis of the SEER database

AU - Li, Mu

AU - Dai, Chen Yang

AU - Wang, Yu Ning

AU - Chen, Tao

AU - Wang, Long

AU - Yang, Ping

AU - Xie, Dong

AU - Mao, Rui

AU - Chen, Chang

PY - 2016

Y1 - 2016

N2 - Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.

AB - Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.

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KW - SEER

KW - Socio-economics

KW - Survival analysis

KW - Tracheal cancer

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