Marine Invertebrate Natural Products that Target Microtubules

John H. Miller; Jessica J. Field; Arun Kanakkanthara; Jeremy G. Owen; A. Jonathan Singh; Peter T. Northcote

doi:10.1021/acs.jnatprod.7b00964

Marine Invertebrate Natural Products that Target Microtubules

John H. Miller, Jessica J. Field, Arun Kanakkanthara, Jeremy G. Owen, A. Jonathan Singh, Peter T. Northcote

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts.

Original language	English (US)
Pages (from-to)	691-702
Number of pages	12
Journal	Journal of Natural Products
Volume	81
Issue number	3
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00964
State	Published - Mar 23 2018

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.7b00964

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title = "Marine Invertebrate Natural Products that Target Microtubules",

abstract = "Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts.",

author = "Miller, {John H.} and Field, {Jessica J.} and Arun Kanakkanthara and Owen, {Jeremy G.} and Singh, {A. Jonathan} and Northcote, {Peter T.}",

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AU - Miller, John H.

AU - Field, Jessica J.

AU - Kanakkanthara, Arun

AU - Owen, Jeremy G.

AU - Singh, A. Jonathan

AU - Northcote, Peter T.

PY - 2018/3/23

Y1 - 2018/3/23

N2 - Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts.

AB - Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts.

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Marine Invertebrate Natural Products that Target Microtubules

Abstract

ASJC Scopus subject areas

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