Marine Invertebrate Natural Products that Target Microtubules

John H. Miller, Jessica J. Field, Arun Kanakkanthara, Jeremy G. Owen, A. Jonathan Singh, Peter T. Northcote

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Marine natural products as secondary metabolites are a potential major source of new drugs for treating disease. In some cases, cytotoxic marine metabolites target the microtubules of the eukaryote cytoskeleton for reasons that will be discussed. This review covers the microtubule-targeting agents reported from sponges, corals, tunicates, and molluscs and the evidence that many of these secondary metabolites are produced by bacterial symbionts. The review finishes by discussing the directions for future development and production of clinically relevant amounts of these natural products and their analogues through aquaculture, chemical synthesis, and biosynthesis by bacterial symbionts.

Original languageEnglish (US)
Pages (from-to)691-702
Number of pages12
JournalJournal of Natural Products
Volume81
Issue number3
DOIs
StatePublished - Mar 23 2018

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Miller, J. H., Field, J. J., Kanakkanthara, A., Owen, J. G., Singh, A. J., & Northcote, P. T. (2018). Marine Invertebrate Natural Products that Target Microtubules. Journal of Natural Products, 81(3), 691-702. https://doi.org/10.1021/acs.jnatprod.7b00964