Marijuana intoxication and brain activation in marijuana smokers

Roy J. Mathew, William H. Wilson, R. Edward Coleman, Timothy G. Turkington, Timothy R DeGrado

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Objective and Method: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (IV) infusion of either of two doses of THC or a placebo, given under double blind conditions. Results: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. Conclusion: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus.

Original languageEnglish (US)
Pages (from-to)2075-2089
Number of pages15
JournalLife Sciences
Volume60
Issue number23
DOIs
StatePublished - May 2 1997
Externally publishedYes

Fingerprint

Dronabinol
Cannabis
Cerebrovascular Circulation
Brain
Chemical activation
Blood
Gyrus Cinguli
Placebos
Positron emission tomography
Regional Blood Flow
Frontal Lobe
Intravenous Infusions
Regression analysis
Positron-Emission Tomography
Volunteers
Regression Analysis
Water

Keywords

  • cerebral blood flow
  • delta tetrahydrocannabinol
  • positron emission tomography

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mathew, R. J., Wilson, W. H., Coleman, R. E., Turkington, T. G., & DeGrado, T. R. (1997). Marijuana intoxication and brain activation in marijuana smokers. Life Sciences, 60(23), 2075-2089. https://doi.org/10.1016/S0024-3205(97)00195-1

Marijuana intoxication and brain activation in marijuana smokers. / Mathew, Roy J.; Wilson, William H.; Coleman, R. Edward; Turkington, Timothy G.; DeGrado, Timothy R.

In: Life Sciences, Vol. 60, No. 23, 02.05.1997, p. 2075-2089.

Research output: Contribution to journalArticle

Mathew, RJ, Wilson, WH, Coleman, RE, Turkington, TG & DeGrado, TR 1997, 'Marijuana intoxication and brain activation in marijuana smokers', Life Sciences, vol. 60, no. 23, pp. 2075-2089. https://doi.org/10.1016/S0024-3205(97)00195-1
Mathew, Roy J. ; Wilson, William H. ; Coleman, R. Edward ; Turkington, Timothy G. ; DeGrado, Timothy R. / Marijuana intoxication and brain activation in marijuana smokers. In: Life Sciences. 1997 ; Vol. 60, No. 23. pp. 2075-2089.
@article{6d553883b75747e9849aa9f2b4e03562,
title = "Marijuana intoxication and brain activation in marijuana smokers",
abstract = "Objective and Method: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (IV) infusion of either of two doses of THC or a placebo, given under double blind conditions. Results: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. Conclusion: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus.",
keywords = "cerebral blood flow, delta tetrahydrocannabinol, positron emission tomography",
author = "Mathew, {Roy J.} and Wilson, {William H.} and Coleman, {R. Edward} and Turkington, {Timothy G.} and DeGrado, {Timothy R}",
year = "1997",
month = "5",
day = "2",
doi = "10.1016/S0024-3205(97)00195-1",
language = "English (US)",
volume = "60",
pages = "2075--2089",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "23",

}

TY - JOUR

T1 - Marijuana intoxication and brain activation in marijuana smokers

AU - Mathew, Roy J.

AU - Wilson, William H.

AU - Coleman, R. Edward

AU - Turkington, Timothy G.

AU - DeGrado, Timothy R

PY - 1997/5/2

Y1 - 1997/5/2

N2 - Objective and Method: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (IV) infusion of either of two doses of THC or a placebo, given under double blind conditions. Results: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. Conclusion: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus.

AB - Objective and Method: The acute effects of delta9 tetrahydrocannabinol (THC) on cerebral blood flow (CBF) were studied in human subjects. Regional CBF was measured with 15O-water and Positron Emission Tomography (PET) in 32 volunteers with a history of exposure to marijuana. Scans were performed before and after intravenous (IV) infusion of either of two doses of THC or a placebo, given under double blind conditions. Results: THC but not placebo increased CBF especially in the frontal regions bilaterally, insula and cingulate gyrus and sub-cortical regions with somewhat greater effects in the right hemisphere. While most regions showed significant change at 60 minutes for the lower dose group, the higher dose group had significant change at 30 and 60 minutes. There was a highly significant change in the anterior/posterior ratio for the two THC groups reflecting minimal change in occipital flow but significant increases in frontal flow. Self ratings of THC intoxication showed significant effects, and regression analysis indicated it correlated most markedly with the right frontal region. Conclusion: Behavioral manifestations of marijuana intoxication may be associated with increased functional activity of the brain especially the frontal cortex, insula and cingulate gyrus.

KW - cerebral blood flow

KW - delta tetrahydrocannabinol

KW - positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0030928428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030928428&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(97)00195-1

DO - 10.1016/S0024-3205(97)00195-1

M3 - Article

C2 - 9180362

AN - SCOPUS:0030928428

VL - 60

SP - 2075

EP - 2089

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 23

ER -