Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer

Jamie Wagner, Judy C. Boughey, Betsy Garrett, Gildy Babiera, Henry Kuerer, Funda Meric-Bernstam, Eva Singletary, Kelly K. Hunt, Lavinia P. Middleton, Isabelle Bedrosian

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12 Scopus citations

Abstract

Background: Optimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients. Methods: Ninety-three (30%) of 311 patients with ILC received NAC. We examined margin status, residual disease after re-excision, and clinical outcomes. Results: Margin positivity rates after the final operative procedure were similar between the NAC and surgery-first group (P > .05). The proportion of patients, stratified by margin status, who were taken back for re-excision was not different between the 2 groups, and, similarly, there were no differences in frequency of residual disease (all P > .05). At a median follow-up of 3.1 years, 1 patient in the NAC group and 2 in the surgery-first group developed LR (P = 1.0). Conclusions: Patients with ILC who have undergone NAC and have margins >1 mm have a low probability of residual disease and LR.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalAmerican journal of surgery
Volume198
Issue number3
DOIs
StatePublished - Sep 1 2009

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Keywords

  • Breast
  • Lobular cancer
  • Local recurrence
  • Margins
  • Neoadjuvant chemotherapy

ASJC Scopus subject areas

  • Surgery

Cite this

Wagner, J., Boughey, J. C., Garrett, B., Babiera, G., Kuerer, H., Meric-Bernstam, F., Singletary, E., Hunt, K. K., Middleton, L. P., & Bedrosian, I. (2009). Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer. American journal of surgery, 198(3), 387-391. https://doi.org/10.1016/j.amjsurg.2009.01.006