MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies

Catherine Labbé, Michael G. Heckman, Oswaldo Lorenzo-Betancor, Alexandra I. Soto-Ortolaza, Ronald L. Walton, Melissa E. Murray, Mariet Allen, Ryan J. Uitti, Zbigniew K. Wszolek, Glenn E. Smith, Kejal Kantarci, David S. Knopman, Val J. Lowe, Clifford R. Jack, Nilüfer Ertekin-Taner, Anhar Hassan, Rodolfo Savica, Ronald C. Petersen, Joseph E. Parisi, Demetrius M. MaraganoreNeill R. Graff-Radford, Tanis J. Ferman, Bradley F. Boeve, Dennis W. Dickson, Owen A. Ross

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Introduction The MAPT H1 haplotype has been associated with several neurodegenerative diseases. We were interested in exploring the role of MAPT haplotypic variation in risk of dementia with Lewy bodies (DLB). Method We genotyped six MAPT haplotype tagging SNPs and screened 431 clinical DLB cases, 347 pathologically defined high-likelihood DLB cases, and 1049 controls. Result We performed haplotypic association tests and detected an association with the protective H2 haplotype in our combined series (odds ratio [OR] = 0.75). We fine-mapped the locus and identified a relatively rare haplotype, H1G, that is associated with an increased risk of DLB (OR = 3.30, P = .0017). This association was replicated in our pathologically defined series (OR = 2.26, P = .035). Discussion These results support a role for H1 and specifically H1G in susceptibility to DLB. However, the exact functional variant at the locus is still unknown, and additional studies are warranted to fully explain genetic risk of DLB at the MAPT locus.

Original languageEnglish (US)
Pages (from-to)1297-1304
Number of pages8
JournalAlzheimer's and Dementia
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2016

Keywords

  • Dementia with Lewy bodies
  • Genetic association study
  • Lewy body disease
  • MAPT
  • tau protein

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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