Mapping ventricular expansion onto cortical gray matter in older adults

for the Alzheimer's Disease Neuroimaging Initiative (ADNI)

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N= 677) and 2-year (N= 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression.

Original languageEnglish (US)
Pages (from-to)S32-S41
JournalNeurobiology of Aging
Volume36
Issue numberS1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Alzheimer Disease
Atrophy
Disease Progression
Biomarkers
Parietal Lobe
Lateral Ventricles
Brain
Temporal Lobe
Cognition
Magnetic Resonance Imaging
Clinical Trials
Gray Matter
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Biomarkers
  • Brain imaging
  • Brain structure
  • Cortical
  • Gray matter
  • Longitudinal
  • Magnetic resonance imaging (MRI)
  • Mild cognitive impairment
  • Surface area
  • Thickness
  • Volume

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Mapping ventricular expansion onto cortical gray matter in older adults. / for the Alzheimer's Disease Neuroimaging Initiative (ADNI).

In: Neurobiology of Aging, Vol. 36, No. S1, 01.01.2015, p. S32-S41.

Research output: Contribution to journalArticle

for the Alzheimer's Disease Neuroimaging Initiative (ADNI) 2015, 'Mapping ventricular expansion onto cortical gray matter in older adults', Neurobiology of Aging, vol. 36, no. S1, pp. S32-S41. https://doi.org/10.1016/j.neurobiolaging.2014.03.044
for the Alzheimer's Disease Neuroimaging Initiative (ADNI). / Mapping ventricular expansion onto cortical gray matter in older adults. In: Neurobiology of Aging. 2015 ; Vol. 36, No. S1. pp. S32-S41.
@article{43c7cc4ff1d641bea93c46bb2025ec79,
title = "Mapping ventricular expansion onto cortical gray matter in older adults",
abstract = "Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N= 677) and 2-year (N= 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression.",
keywords = "Alzheimer's disease, Biomarkers, Brain imaging, Brain structure, Cortical, Gray matter, Longitudinal, Magnetic resonance imaging (MRI), Mild cognitive impairment, Surface area, Thickness, Volume",
author = "{for the Alzheimer's Disease Neuroimaging Initiative (ADNI)} and Madsen, {Sarah K.} and Gutman, {Boris A.} and Joshi, {Shantanu H.} and Toga, {Arthur W.} and Jack, {Clifford R Jr.} and Weiner, {Michael W.} and Thompson, {Paul M.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.neurobiolaging.2014.03.044",
language = "English (US)",
volume = "36",
pages = "S32--S41",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "S1",

}

TY - JOUR

T1 - Mapping ventricular expansion onto cortical gray matter in older adults

AU - for the Alzheimer's Disease Neuroimaging Initiative (ADNI)

AU - Madsen, Sarah K.

AU - Gutman, Boris A.

AU - Joshi, Shantanu H.

AU - Toga, Arthur W.

AU - Jack, Clifford R Jr.

AU - Weiner, Michael W.

AU - Thompson, Paul M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N= 677) and 2-year (N= 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression.

AB - Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N= 677) and 2-year (N= 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression.

KW - Alzheimer's disease

KW - Biomarkers

KW - Brain imaging

KW - Brain structure

KW - Cortical

KW - Gray matter

KW - Longitudinal

KW - Magnetic resonance imaging (MRI)

KW - Mild cognitive impairment

KW - Surface area

KW - Thickness

KW - Volume

UR - http://www.scopus.com/inward/record.url?scp=84916623265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916623265&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2014.03.044

DO - 10.1016/j.neurobiolaging.2014.03.044

M3 - Article

C2 - 25311280

AN - SCOPUS:84916623265

VL - 36

SP - S32-S41

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - S1

ER -