Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Xing Li, Katherine A. Campbell, Sherri M. Biendarra, Andre Terzic, Timothy J Nelson

Research output: Contribution to journalArticle

Abstract

The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3-/- mouse embryonic heart ventricular tissues at 14.5days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3-/- mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both in utero (using embryonic heart tissues) and in vitro (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE69317).

Original languageEnglish (US)
Pages (from-to)129-130
Number of pages2
JournalGenomics Data
Volume7
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Cardiac development
  • Disease modeling
  • Induced pluripotent stem cell
  • Microarray analysis
  • Nos3 knockout

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry
  • Biotechnology
  • Genetics

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