Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Xing Li; Katherine A. Campbell; Sherri M. Biendarra; Andre Terzic; Timothy J. Nelson

doi:10.1016/j.gdata.2015.12.022

Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Xing Li, Katherine A. Campbell, Sherri M. Biendarra, Andre Terzic, Timothy J. Nelson

Research output: Contribution to journal › Article › peer-review

Abstract

The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3^-/- mouse embryonic heart ventricular tissues at 14.5days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3^-/- mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both in utero (using embryonic heart tissues) and in vitro (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE69317).

Original language	English (US)
Pages (from-to)	129-130
Number of pages	2
Journal	Genomics Data
Volume	7
DOIs	https://doi.org/10.1016/j.gdata.2015.12.022
State	Published - Mar 1 2016

Keywords

Cardiac development
Disease modeling
Induced pluripotent stem cell
Microarray analysis
Nos3 knockout

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Medicine
Genetics

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10.1016/j.gdata.2015.12.022

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title = "Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development",

abstract = "The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3-/- mouse embryonic heart ventricular tissues at 14.5days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3-/- mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both in utero (using embryonic heart tissues) and in vitro (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE69317).",

keywords = "Cardiac development, Disease modeling, Induced pluripotent stem cell, Microarray analysis, Nos3 knockout",

author = "Xing Li and Campbell, {Katherine A.} and Biendarra, {Sherri M.} and Andre Terzic and Nelson, {Timothy J.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2016",

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doi = "10.1016/j.gdata.2015.12.022",

language = "English (US)",

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AU - Li, Xing

AU - Campbell, Katherine A.

AU - Biendarra, Sherri M.

AU - Terzic, Andre

AU - Nelson, Timothy J.

PY - 2016/3/1

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N2 - The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3-/- mouse embryonic heart ventricular tissues at 14.5days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3-/- mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both in utero (using embryonic heart tissues) and in vitro (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE69317).

AB - The dataset includes microarray data (Affymetrix Mouse Genome 430 2.0 Array) from WT and Nos3-/- mouse embryonic heart ventricular tissues at 14.5days post coitum (E14.5), induced pluripotent stem cells (iPSCs) derived from WT and Nos3-/- mouse tail tip fibroblasts, iPSC-differentiated cardiomyocytes at Day 11, and mouse embryonic stem cells (mESCs) and differentiated cardiomyocytes as positive controls for mouse iPSC differentiation. Both in utero (using embryonic heart tissues) and in vitro (using iPSCs and differentiated cells) microarray datasets were deposited to the NCBI Gene Expression Omnibus (GEO) database. The deposited data in GEO include raw microarray data, metadata for sample source information, experimental design, sample and data processing, and gene expression matrix. The data are available under GEO Access Number GSE69317 (GSE69315 for tissue sample microarray data, GSE69316 for iPSCs microarray data, http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc= GSE69317).

KW - Cardiac development

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KW - Induced pluripotent stem cell

KW - Microarray analysis

KW - Nos3 knockout

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Mapping transcriptome profiles of in vitro iPSC-derived cardiac differentiation to in utero heart development

Abstract

Keywords

ASJC Scopus subject areas

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