TY - JOUR
T1 - Mapping studies and expression of genes located on human chromosome 11, band q23
AU - Savage, Paul D.
AU - Jones, C.
AU - Silver, J.
AU - Van Geurts Kessel, A. H.M.
AU - Gonzalez-Sarmiento, R.
AU - Palm, L.
AU - Hanson, C. A.
AU - Kersey, J. H.
PY - 1988
Y1 - 1988
N2 - Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen—NCAM—CD3([G, D], E)—//—(ETS1, THY1)—11qter.
AB - Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen—NCAM—CD3([G, D], E)—//—(ETS1, THY1)—11qter.
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U2 - 10.1159/000132680
DO - 10.1159/000132680
M3 - Article
C2 - 3248386
AN - SCOPUS:0024149553
SN - 0301-0171
VL - 49
SP - 289
EP - 292
JO - Cytogenetics and Cell Genetics
JF - Cytogenetics and Cell Genetics
IS - 4
ER -