Mapping studies and expression of genes located on human chromosome 11, band q23

Paul D. Savage, C. Jones, J. Silver, A. H.M. Van Geurts Kessel, R. Gonzalez-Sarmiento, L. Palm, C. A. Hanson, J. H. Kersey

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen—NCAM—CD3([G, D], E)—//—(ETS1, THY1)—11qter.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalCytogenetic and Genome Research
Volume49
Issue number4
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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