Mapping of the α4 subunit gene (GABRA4) to human chromosome 4 defines an α2411 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster

Pamela J McLean, David H. Farb, Shelley J. Russek

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We demonstrated previously that an α122 gene cluster of the γ-aminobutyric acid (GABAA) receptor is located on human chromosome 5q34-q35 and that an ancestral α-β-γ gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here, we report that the α4 gene (GABRA4) maps to human chromosome 4p14-q12, defining a cluster comprising the α2, α4, β1, and γ1 genes. The existence of an α2411 cluster on chromosome 4 and an α1622 cluster on chromosome 5 provides further evidence that the number of ancestral GABAA receptor subunit genes has been expanded by duplication within an ancestral gene cluster. Moreover, if duplication of the α gene occurred before duplication of the ancestral gene cluster, then a heretofore undiscovered subtype of α subunit should be located on human chromosome 15q11-q13 within an α5x33 gene cluster at the locus for Angelman and Prader-Willi syndromes.

Original languageEnglish (US)
Pages (from-to)580-586
Number of pages7
JournalGenomics
Volume26
Issue number3
DOIs
StatePublished - Apr 10 1995
Externally publishedYes

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Chromosomes, Human, Pair 4
Human Chromosomes
GABA-A Receptors
Multigene Family
Chromosomes, Human, Pair 5
Genes
Aminobutyrates
Prader-Willi Syndrome
Chromosomes, Human, Pair 15
Gene Duplication
Chromosomes, Human, Pair 1

ASJC Scopus subject areas

  • Genetics

Cite this

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title = "Mapping of the α4 subunit gene (GABRA4) to human chromosome 4 defines an α2-α4-β1-γ1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster",
abstract = "We demonstrated previously that an α1-β2-γ2 gene cluster of the γ-aminobutyric acid (GABAA) receptor is located on human chromosome 5q34-q35 and that an ancestral α-β-γ gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here, we report that the α4 gene (GABRA4) maps to human chromosome 4p14-q12, defining a cluster comprising the α2, α4, β1, and γ1 genes. The existence of an α2-α4-β1-γ1 cluster on chromosome 4 and an α1-α6-β2-γ2 cluster on chromosome 5 provides further evidence that the number of ancestral GABAA receptor subunit genes has been expanded by duplication within an ancestral gene cluster. Moreover, if duplication of the α gene occurred before duplication of the ancestral gene cluster, then a heretofore undiscovered subtype of α subunit should be located on human chromosome 15q11-q13 within an α5-αx-β3-γ3 gene cluster at the locus for Angelman and Prader-Willi syndromes.",
author = "McLean, {Pamela J} and Farb, {David H.} and Russek, {Shelley J.}",
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AU - McLean, Pamela J

AU - Farb, David H.

AU - Russek, Shelley J.

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Y1 - 1995/4/10

N2 - We demonstrated previously that an α1-β2-γ2 gene cluster of the γ-aminobutyric acid (GABAA) receptor is located on human chromosome 5q34-q35 and that an ancestral α-β-γ gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here, we report that the α4 gene (GABRA4) maps to human chromosome 4p14-q12, defining a cluster comprising the α2, α4, β1, and γ1 genes. The existence of an α2-α4-β1-γ1 cluster on chromosome 4 and an α1-α6-β2-γ2 cluster on chromosome 5 provides further evidence that the number of ancestral GABAA receptor subunit genes has been expanded by duplication within an ancestral gene cluster. Moreover, if duplication of the α gene occurred before duplication of the ancestral gene cluster, then a heretofore undiscovered subtype of α subunit should be located on human chromosome 15q11-q13 within an α5-αx-β3-γ3 gene cluster at the locus for Angelman and Prader-Willi syndromes.

AB - We demonstrated previously that an α1-β2-γ2 gene cluster of the γ-aminobutyric acid (GABAA) receptor is located on human chromosome 5q34-q35 and that an ancestral α-β-γ gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here, we report that the α4 gene (GABRA4) maps to human chromosome 4p14-q12, defining a cluster comprising the α2, α4, β1, and γ1 genes. The existence of an α2-α4-β1-γ1 cluster on chromosome 4 and an α1-α6-β2-γ2 cluster on chromosome 5 provides further evidence that the number of ancestral GABAA receptor subunit genes has been expanded by duplication within an ancestral gene cluster. Moreover, if duplication of the α gene occurred before duplication of the ancestral gene cluster, then a heretofore undiscovered subtype of α subunit should be located on human chromosome 15q11-q13 within an α5-αx-β3-γ3 gene cluster at the locus for Angelman and Prader-Willi syndromes.

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